Table 3.

Hematological parameters of male/female rats treated with HU033 in the 13-week repeated oral dose toxicity study (results are presented as the mean ± SD, n = 10)

Parameters	Dose (mg/kg/day)
	0	500	1000	2000
No. of rats	10	10	10	10
Male
RBC (× 106cells/μL)	8.38 ± 0.41	8.48 ± 0.36	8.61 ± 0.50	8.61 ± 0.35
HGB (g/dL)	14.6 ± 0.7	14.5 ± 0.4	14.4 ± 0.7	14.7 ± 0.4
HCT (%)	44.1 ± 2.0	43.9 ± 1.2	43.6 ± 2.1	44.4 ± 1.0
MCV (fL)	52.7 ± 1.6	51.8 ± 1.7	50.8 ± 1.6	51.7 ± 2.5
MCH (pg)	17.5 ± 0.6	17.1 ± 0.7	16.8 ± 0.5	17.1 ± 0.9
MCHC (g/dL)	33.2 ± 0.5	33.0 ± 0.4	33.0 ± 0.4	33.2 ± 0.4
PLT (× 103 cells/μL)	925 ± 123	885 ± 74	863 ± 92	869 ± 75
WBC (× 103 cells/μL)	7.45 ± 1.55	8.85 ± 2.85	7.68 ± 2.44	8.68 ± 2.52
NEU (%)	22.8 ± 7.2	20.1 ± 4.8	19.6 ± 8.3	22.4 ± 8.2
LYM (%)	72.0 ± 6.9	74.9 ± 4.9	75.4 ± 8.7	72.6 ± 8.0
MONO (%)	2.3 ± 0.7	2.2 ± 0.7	2.1 ± 0.4	2.4 ± 0.6
EOS (%)	1.2 ± 0.4	1.1 ± 0.3	1.1 ± 0.5	1.1 ± 0.4
BASO (%)	0.2 ± 0.1	0.2 ± 0.1	0.2 ± 0.1	0.2 ± 0.1
Female
RBC (× 106cells/μL)	7.86 ± 0.24	7.99 ± 0.27	8.11 ± 0.25	7.94 ± 0.45
HGB (g/dL)	14.7 ± 0.6	14.7 ± 0.3	14.8 ± 0.3	14.6 ± 0.6
HCT (%)	42.6 ± 1.7	43.1 ± 1.4	43.1 ± 0.9	42.9 ± 1.7
MCV (fL)	54.2 ± 1.0	53.9 ± 1.0	53.1 ± 1.0	54.1 ± 1.7
MCH (pg)	18.7 ± 0.4	18.5 ± 0.4	18.3 ± 0.5	18.5 ± 0.6
MCHC (g/dL)	34.4 ± 0.3	34.3 ± 0.5	34.4 ± 0.5	34.1 ± 0.4
PLT (× 103 cells/μL)	928 ± 84	870 ± 77	843 ± 71	861 ± 72
WBC (× 103 cells/μL)	4.70 ± 1.45	5.03 ± 1.82	5.12 ± 2.40	4.41 ± 1.32
NEU (%)	18.1 ± 7.9	17.4 ± 7.3	11.9 ± 4.2	17.4 ± 7.2
LYM (%)	77.6 ± 7.8	77.4 ± 8.3	83.7 ± 4.4	77.9 ± 7.5
MONO (%)	1.9 ± 0.4	2.1 ± 0.7	2.0 ± 0.5	2.1 ± 0.8
EOS (%)	1.3 ± 0.5	1.7 ± 0.7	1.1 ± 0.5	1.5 ± 0.5
BASO (%)	0.1 ± 0.1	0.2 ± 0.1	0.2 ± 0.1	0.2 ± 0.1

RBC red blood cell count, HGB hemoglobin, HCT hematocrit, MCV mean corpuscular volume, MCH mean corpuscular hemoglobin, MCHC mean corpuscular hemoglobin concentration, PLT platelet, WBC white blood cell count, NEU neutrophils, LYM lymphocytes, MONO monocyte, EOS eosinophils, BASO basophils