Table 4.

Serum biochemistry values of male and female rats treated with HU033 in the 13-week repeated oral dose toxicity study (results are presented as the mean ± SD, n = 10)

Parameters	Dose (mg/kg/day)
	0	500	1000	2000
No. of rats	10	10	10	10
Male
ALT (U/L)	29.6 ± 6.9	26.1 ± 6.2	27.0 ± 7.1	24.4 ± 7.9
AST (U/L)	76.6 ± 19.3	77.8 ± 22.5	71.7 ± 14.9	75.5 ± 16.0
ALP (U/L)	291.1 ± 88.2	244.9 ± 32.5	252.4 ± 45.2	246.4 ± 42.9
GGT (U/L)	0.27 ± 0.14	0.27 ± 0.12	0.27 ± 0.08	0.35 ± 0.13
Glu (mg/dL)	143 ± 17	139 ± 8	154 ± 16	148 ± 10
BUN (mg/dL)	12.4 ± 1.5	11.7 ± 1.4	11.1 ± 1.8	12.0 ± 1.8
Crea (mg/dL)	0.41 ± 0.02	0.39 ± 0.03	0.39 ± 0.06	0.40 ± 0.03
T-chol (mg/dL)	83 ± 13	79 ± 17	78 ± 33	74 ± 14
TG (mg/dL)	51 ± 24	67 ± 28	54 ± 13	70 ± 23
TP (mg/dL)	5.9 ± 0.3	5.9 ± 0.3	5.9 ± 0.2	5.9 ± 0.3
Alb (g/dL)	2.4 ± 0.1	2.4 ± 0.1	2.4 ± 0.2	2.4 ± 0.1
P (mg/dL)	5.78 ± 0.65	5.53 ± 0.74	5.32 ± 0.87	5.63 ± 0.90
Ca (mg/dL)	9.9 ± 0.8	10.2 ± 0.3	10.1 ± 0.4	10.0 ± 0.5
Female
ALT (U/L)	28.3 ± 11.9	48.6 ± 50.4	28.3 ± 7.3	29.7 ± 18.8
AST (U/L)	76.3 ± 23.6	80.7 ± 36.5	61.5 ± 9.2	79.9 ± 54.4
ALP (U/L)	142.8 ± 39.9	142.9 ± 36.9	119.5 ± 36.7	149.7 ± 37.2
GGT (U/L)	0.66 ± 0.23	0.72 ± 0.19	0.61 ± 0.31	0.64 ± 0.24
Glu (mg/dL)	133 ± 10	144 ± 12	139 ± 11	140 ± 13
BUN (mg/dL)	15.1 ± 1.3	13.1 ± 2.0	14.1 ± 2.2	13.6 ± 1.4
Crea (mg/dL)	0.49 ± 0.03	0.45 ± 0.03	0.46 ± 0.05	0.45 ± 0.04
T-chol (mg/dL)	91 ± 12	82 ± 8	91 ± 14	87 ± 12
TG (mg/dL)	21 ± 17	18 ± 7	25 ± 9	25 ± 10
TP (mg/dL)	6.3 ± 0.4	6.1 ± 0.2	6.3 ± 0.5	6.0 ± 0.4
Alb (g/dL)	2.8 ± 0.3	2.7 ± 0.1	2.9 ± 0.4	2.6 ± 0.2
P (mg/dL)	4.45 ± 0.58	4.28 ± 0.68	4.14 ± 0.60	4.36 ± 0.68
Ca (mg/dL)	9.8 ± 0.4	9.9 ± 0.3	9.9 ± 0.2	9.5 ± 0.5

ALT alanine aminotransferase, AST aspartate aminotransferase, ALP alkaline phosphatase, GGT gamma glutamyl transpeptidase, BUN blood urea nitrogen, Crea creatinine, TP total protein, Alb albumin, T-chlo total cholesterol, TG triglycerides, P phosphorus, Glu glucose, Ca calcium