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. 2022 Jun 30;12(10):3843–3860. doi: 10.1016/j.apsb.2022.06.013

Figure 1.

Figure 1

Discovery of SolA as a neuroprotective small-molecule against AGEs-induced injury. (A) SolA increased the cell viability in AGEs-induced PC12 cells (n = 3). (B) SolA decreased LDH release in AGEs-induced PC12 cells (n = 4). (C) SolA inhibited PC12 cells apoptosis by Hoechst 33258 staining (scale bar: 100 μm, n = 5). Arrows indicate brightly stained nuclei for apoptosis. (D) SolA inhibited PC12 cells apoptosis by double staining with AO and EB (scale bar: 100 μm, n = 3). Arrows indicate orange apoptotic cells. (E) SolA increased the cell viability in AGEs-induced primary neurons (n = 6). (F) SolA inhibited primary neurons apoptosis by Hoechst 33258 staining (scale bar: 100 μm, n = 3). Arrows indicate brightly stained nuclei for apoptosis. Data are expressed as the mean ± SEM. ##P < 0.01 vs. control group, ∗∗P < 0.01 vs. AGEs group.