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Carbohydrate-based antineoplastic nucleosides and nucleotides. (A) The metabolism and resultant toxicity of fludarabine (83). (B) The anticancer nucleoside clofarabine (23) derived from 2′-deoxyadenosine (86). (C) The in vivo metabolism of nelarabine (24). (D) The anticancer nucleoside forodesine (25) which increase the plasma 2′-deoxyguanosine (91).
