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. 2022 Sep 21;10:945586. doi: 10.3389/fcell.2022.945586

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Copyright © 2022 Candido, Tomasello, Lavoro, Falzone, Gattuso, Russo, Paratore, McCubrey and Libra.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Correlation analysis between LCN2 gene/isoforms expression and relative CG probesets methylation levels in each tumor type. (A) Volcano plot showing the correlation between CG probesets and gene/isoforms expression of LCN2 (Pearson’s r ≥ 0.3 and ≤ −0.3, p ≤ 0.01). The top ten hits (five positive and five negative) based on correlation significance are labeled. Blue dots: negative correlation, red dots: positive correlation. (B) Percentage of tumor types, gene/isoforms and CG probesets showing Pearson’s r ≥ 0.3 and ≤ −0.3 (p ≤ 0.01), separately. No more than ten variables with the highest correlation values are indicated.