FIGURE 13.

Synergic effect of promoter hypomethylation and body hypermethylation in the upregulation of SLC22A17. (A) Correlation analysis between gene expression (ENSG00000092096.14) and CG probesets methylation levels of SLC22A17 was evaluated for each tumor type. Only CG probesets showing Pearson’s r ≥ 0.3 (magenta circles) and r ≤ −0.3 (green circles) p (≤0.05) are included. Magenta dots indicate the cg16420801 probeset while green dots represent the cg23464698 probeset. Green label indicates tumor types in which both CG probesets are significantly correlated. (B) Differential analysis (two-tailed unpaired t-test) of SLC22A17 (ENSG00000092096.14) expression was performed stratifying the tumor samples in different four groups based on the methylation levels of cg16420801 and cg23464698 probesets with respect to the mean value calculated for each CG probeset in all tumor samples. FC and pValue are reported for each comparing group.