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. 2022 Sep 21;10:945586. doi: 10.3389/fcell.2022.945586

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Copyright © 2022 Candido, Tomasello, Lavoro, Falzone, Gattuso, Russo, Paratore, McCubrey and Libra.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Correlation analysis between LCN2, SLC22A17, and MMP9 gene/isoforms expression and protein levels in PANCAN tumor samples. Correlation with Pearson’s r ≥ 0.3 or ≤ −0.3 and p ≤ 0.05 are included in the heatmap. The average linkage clustering method and Euclidean distance measurement method were applied for grouping similar data in seven representative clusters. Each protein is labeled with three different colors corresponding to 1, 6, and 9 tumor groups (Supplementary Table S6). Black bold labels indicate the LCN2, SLC22A17, and MMP9 genes (ENSG). Coding ENST isoforms: blue; non-coding ENST isoforms: green; retained intron ENST isoforms: red.