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. 2022 Sep 21;10:945586. doi: 10.3389/fcell.2022.945586

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Copyright © 2022 Candido, Tomasello, Lavoro, Falzone, Gattuso, Russo, Paratore, McCubrey and Libra.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Correlation analysis between LCN2, SLC22A17, and MMP9 gene expression and protein levels in tumor types. Protein-gene interaction showing correlation (Pearson’s r ≥ 0.3 or ≤ −0.3; p ≤ 0.05) in at least five tumor types are reported. The concordance among Pearson’s values was defined as the degree of agreement among the correlation sign. Partial concordance: dotted interaction lines. Total concordance: solid interaction lines. Proteins interacting with two genes are represented in blue, while proteins interacting with all three genes are represented in orange. The network was obtained from Cytoscape 3.8.2 (https://cytoscape.org/).