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. 2022 Sep 21;13:1011566. doi: 10.3389/fphys.2022.1011566

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Copyright © 2022 Strocchi, Gillette, Neic, Elliott, Wijesuriya, Mehta, Vigmond, Plank, Rinaldi and Niederer.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Response with LV His-Purkinje, whole His-Purkinje and myocardium conduction slowing: LVAT-95, LVDI, RVAT-95, RVDI, BIVAT-90, and BIVDI simulated in the presence of proximal RBBB combined with otherwise normal His-Purkinje system (blue bars) and: (A) mild (orange bars) and severe (green bars) LV His-Purkinje conduction slowing; (B) mild (orange bars) and severe (green bars) His-Purkinje conduction slowing; (C) mild (orange bars) and severe (green bars) myocardium conduction slowing. Activation was simulated during baseline, standard CRT, selective HBP (S-HBP) and selective LBP (S-LBP). Results are presented as mean ± standard deviation.