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. 2022 Sep 21;12:988119. doi: 10.3389/fonc.2022.988119

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Copyright © 2022 Charlestin, Fulkerson, Arias Matus, Walker, Carthy and Littlepage

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Aquaporin Structure and Function Relevant to Breast Cancer. (A) Cartoon representation of AQP monomer topology. The transmembrane helices 1-6, extracellular loops (A, C, E), intracellular loops (B, D). Singled-letter N-P-A codes in pink circles mark the NPA motifs and ar/R in purple circles. (B) Organization of helices and NPA motifs on the loops bend to pair with each other and form the water channel monomer. (C) AQP monomers assemble as homotetramers to form a central pore. The structure of AQP homotetramer from the top view shows each AQP monomer containing an independent water pore. (D) AQP functions that are relevant to breast cancer. Created with BioRender.com. Figures (B, C) were modified from Reference (12) with permission. Figure (D) was modified from reference (9) with permission