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. 2022 Sep 21;12:988119. doi: 10.3389/fonc.2022.988119

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Copyright © 2022 Charlestin, Fulkerson, Arias Matus, Walker, Carthy and Littlepage

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Roles of Aquaporins in Breast Cancer. In breast cancer, individual AQPs have multiple roles, from proliferation to migration to intravasation, where the cancer cells then metastasize to a secondary site. Metabolic reprogramming of cancer cells helps to support proliferation as AQPs can help to facilitate glycerol transport. In cancer-associated adipocytes (CAAs), AQP expression may be essential in facilitating glycerol transport between CAAs and cancer cells. AQP3 expression is critical in cell migration where changes in signal transduction pathways facilitate migration and AQP3 overexpression. Created with BioRender.com. This figure was influenced by Aikman et al. (83).