Table 2.
ROC Analysis of Pathological Complete Response of AQPs for Breast Cancer. ROC Plotter links gene expression and response to therapy using transcriptome-level data of breast cancer patients.
| Gene | AQP Expression for Responders | Treatment | Subtype | AUC | ROC p value | Mann Whitney t test | Fold change | Dataset |
|---|---|---|---|---|---|---|---|---|
| AQP2 | High | Any anti-HER2 | All | 0.605 | 0.0036 | 0.0083 | 1.3 | 206672_at |
| AQP2 | High | Any anti-HER2 | HER2+ | 0.611 | 0.0071 | 0.016 | 1.4 | 206672_at |
| AQP4 | High | Any anti-HER2 | All | 0.633 | 0.00022 | 0.00078 | 1.2 | 210066_s_at |
| AQP6 | Low | Aromatase Inhibitor | Luminal A | 0.707 | 0.0023 | 0.029 | 1.2 | 216219_at |
| AQP6 | High | Any anti-HER2 | All | 0.63 | 0.00028 | 0.001 | 1.2 | 216219_at |
| AQP6 | High | Any anti-HER2 | HER2+ER- | 0.686 | 0.0012 | 0.0054 | 1.6 | 216219_at |
| AQP6 | High | Trastuzumab | HER2+ER- | 0.673 | 0.0056 | 0.018 | 1.5 | 216219_at |
| AQP6 | Low | Any Endocrine | All | 0.687 | 0.0038 | 0.019 | 1.2 | 216219_at |
| AQP6 | High | Any anti-HER2 | All | 0.605 | 0.0031 | 0.0079 | 1.1 | 208435_s_at |
| AQP6 | Low | Any Chemotherapy | All | 0.603 | 1.00E-11 | 1.60E-11 | 1.3 | 208435_s_at |
| AQP7 | Low | Anthracycline | TNBC | 0.624 | 8.50E-05 | 0.00028 | 1.2 | 206955_at |
| AQP7 | High | Trastuzumab | HER2+ | 0.605 | 1.70E-02 | 0.037 | 1.3 | 206955_at |
| AQP7 | Low | Aromatase Inhibitor | Luminal A | 0.719 | 3.50E-03 | 0.02 | 1.6 | 206955_at |
| AQP7 | Low | Any Endocrine | All | 0.677 | 0.0097 | 0.027 | 1.6 | 206955_at |
| AQP7 | Low | Any Endocrine | Luminal A | 0.719 | 3.50E-03 | 0.02 | 1.6 | 206955_at |
| AQP8 | Low | Anthracycline | Luminal A | 0.704 | 1.90E-15 | 4.90E-12 | 2.3 | 206784_at |
| AQP8 | Low | Taxane | Luminal A | 0.662 | 0.00000039 | 0.0000053 | 1.8 | 206784_at |
| AQP8 | High | Taxane | HER2+ER- | 0.63 | 0.0026 | 0.0076 | 1.4 | 206784_at |
| AQP10 | High | Any Chemotherapy | Luminal B | 0.634 | 0.013 | 0.03 | 1.6 | 1555338_s_at* |
| AQP10 | High | Anthracycline | HER2+ER- | 0.624 | 0.015 | 0.044 | 1.3 | 1555338_s_at* |
| AQP10 | High | Any anti-HER2 | HER2+ | 0.632 | 0.009 | 0.024 | 1.6 | 1555338_s_at* |
| AQP10 | High | Any anti-HER2 | All | 0.608 | 0.0097 | 0.026 | 1.2 | 1555338_s_at* |
| AQP12B | High | Any Chemotherapy | All | 0.614 | 0.000072 | 0.00016 | 1.5 | 1559575_a_at* |
| AQP12B/AQP12A | High | Any Chemotherapy | All | 0.617 | 0.000061 | 0.00011 | 1.3 | 1554344_s_at* |
| AQP12B/AQP12A | High | Any anti-HER2 | All | 0.605 | 0.013 | 0.031 | 1.3 | 1554344_s_at* |
Area under the curve (AUC) indicates prognostic power of gene. 0.6-0.7, cancer biomarker with potential clinical utility, 0.7-0.8, top quality cancer biomarker, and 0.8+, blockbuster biomarker. AQPs with an AUC > 0.6 and P<0.05, Mann Whitney t test.