Table 3.
Aquaporin Inhibitors. List of available AQP inhibitors and the AQPs they inhibit.
| AQP | Inhibitors in human | Inhibitors in mouse | Inhibitors in rat |
|---|---|---|---|
| AQP1 | Tetraethylammonium (136), HgCl2 (25), AqB007, AqB011 (137), AqB013 (138), acetazolamide, test compounds 1-3 (139), HAuCl4, AgNO3 (140), p-chloromercuribenzoate, DMSO (141), AqF026 (142), Bacopasides (143), furosemide (144) | HgCl2 (145), HAuCl4, AgNO3 (140) | HgCl2, p-hydroxymercuribenzoic sulfonic acid (146), acetazolamide (147) |
| AQP2 | Phenylbenzamides (148) | ||
| AQP3 | HgCl2 (149), Phloretin (150), Auphen (151), CuSO4 (152), NiCl2 (153), DFP00173, Z433927330 (154), polyoxotungstate-Agold (III) complexes (155), gold (III)-Bipyridyl compounds (156) | HgCl2 (157), DFP00173 (154) | Phloretin, p-chloromercuriphenylsulfonate (158), HgCl2, CuSO4 (159) |
| AQP4 | AER-270 (160), 2-(nicotinamido)-1,3,4-thiadiazole, sumatriptan, rizatriptan (161), acetazolamide, 6-Ethoxybenzothiazole-2-sulfonamide (162), 1,3-Oxazoles, Oxazoles with condensed carbocyclic rings, 1,3-Thiazoles, Thiazoles, Thiazoles with condensed carbocyclic rings (163), Topiramate, Zonisamide, Phenytoin, Oxcarbazepine, Lamotrigine, Valproic acid, Carbamazepine-10,11-epoxide (162) | Phenylbenzamides (148) | HgCl2 (164), AqB013, bumetanide (138), acetazolamide (165) |
| AQP5 | CuSO4 (166), HgCl2 (167) | HgCl2 (168) | HgCl2 (169) |
| AQP7 | Auphen (170), monoacetin, monobutyrin, diacetin (171) | Auphen (170) Z433927330 (154) | |
| AQP8 | HgCl2 (172) | HgCl2 (172) | HgCl2 (172, 173), CuSO4 (174) |
| AQP9 | Phloretin, HgCl2 (175, 176), nigericin, carbonyl cyanide 4-trifluoromethoxyphenylhydrazone (177) compounds ID4-6 (178) | Phloretin (179), HTS13286 (180) | Phloretin (181) |
| AQP10 | HgCl2 (182), organometallic gold complexes (183) | ||
| AQP11 | HgCl2 (184) |