TABLE 1.

Role of α1‐blockers in the current management of hypertension

Indication	Epidemiology	Mechanism of action	Treatment effect
Benign prostatic hypertrophy	Up to 25% of hypertensive patients older than 60 years of age	Inhibition of prostatic smooth muscle tone and relaxation of the prostate	Blood pressure lowering and alleviation of lower urinary tract symptoms
Resistant hypertension	13.7% treated hypertension 34	Add‐on therapy	Blood pressure lowering and control
Primary aldosteronism screen	6%–8% in primary care 39 , 40 ; 15% in resistant hypertension 41	No or little effect on plasma aldosterone‐to‐renin ratio	Blood pressure control