FIGURE 12.

FDX1 is downregulated by elesclomol, resulting in inhibiting cell viability in BLCA, ccRCC, and PCa. (A,F,K) The expression level of FDX1 was evaluated in BLCA, ccRCC, and PCa cells and their corresponding normal cells by qRT-PCR and western blot. (B,G,L) The expression level of FDX1 in BLCA, ccRCC, and PCa cell lines treated with elesclomol after 16 h. (E,J,O) The fold Caspase 3/7 activity in BLCA, ccRCC, and PCa cell lines after treated with elesclomol after 16 h. (C,D,H,I,M,N) The cell viability of BLCA, ccRCC, and PCa cell lines after treatment with elesclomol.