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. 2022 Sep 21;13:1005790. doi: 10.3389/fimmu.2022.1005790

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Copyright © 2022 Frischknecht, Deng, Wehmeier, de Rougemont, Villard, Ferrari-Lacraz, Golshayan, Gannagé, Binet, Wirthmueller, Sidler, Schachtner, Schaub, Nilsson and the Swiss Transplant Cohort Study

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Characteristics of the study cohort. (A) Schematic of the workflow illustrating the study overview, the data collection from the clinical and laboratory observations, and main types of analyses in this study. (B) The timeline of the study follow-up on individual patients included after kidney transplantation. The individual lines are colored according to length of follow-up. (C) Overview of the patients with regard to the presence of HLA antibodies (HLA Ab) and DSA. In the samples containing DSA, they are further stratified as “single DSAs”, which refer to patients having only one DSA, as well as “patients with DSA combinations”, which refer to patients having multiple DSA. (D) The distribution of MFI of each DSA directed against individual HLA loci in the investigated patients.