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. 2022 Sep 21;13:1005790. doi: 10.3389/fimmu.2022.1005790

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Copyright © 2022 Frischknecht, Deng, Wehmeier, de Rougemont, Villard, Ferrari-Lacraz, Golshayan, Gannagé, Binet, Wirthmueller, Sidler, Schachtner, Schaub, Nilsson and the Swiss Transplant Cohort Study

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The presence of HLA-DSA is associated with an increased risk of ABMR, graft loss, and loss of kidney function. Cumulative incidence of ABMR (A), TCMR (B), death-censored graft survival (C), and the collective mean annual slope of eGFR (D) in patients without anti-HLA antibodies and without DSA (HLA-DSA-), with anti-HLA antibodies but without DSA (HLA+DSA-) and in patients with DSA (HLA+DSA+) respectively. Log-rank test was used to test p value of the Kaplan-Meier survival curves for (A–C). Two-way ANOVA analysis with Sidak’s multiple comparisons as a post hoc test was used for (D) to assess p values; ****p < 0.0001.