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. 2022 Sep 21;13:1005790. doi: 10.3389/fimmu.2022.1005790

Figure 3.

Figure 3

Pre-transplant DSA directed against HLA Class II antigens showed significantly worse outcomes after kidney transplantation. Cumulative incidence of ABMR (A) and death-censored graft survival (B) in the patient groups with DSA directed against HLA Class I (DSA I), HLA Class II (DSA II), or a combination of Class I and Class II (DSA I+II) and in patients with no DSA. (C) Cumulative incidence of death-censored graft survival in the cohort stratified into groups based on the presence or absence of DSA and ABMR. (D) Death-censored graft survival in patients with ABMR stratified into DSA I, DSA II, DSA I+II, and no DSA groups. The collective mean total slope (E) and mean annual slope (F) of eGFR in the DSA I, DSA II, DSA I+II, and no DSA groups. Log-rank test was used to test p value of the Kaplan-Meier survival curves for (A–D). One-way ANOVA followed by Dunn’s post hoc test for (E) and two-way ANOVA analysis with Sidak’s multiple comparisons as a post hoc test were used for (F) to assess p values; **p < 0.01, ***p < 0.001, ****p < 0.0001.