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. 2022 Sep 21;13:1005790. doi: 10.3389/fimmu.2022.1005790

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Copyright © 2022 Frischknecht, Deng, Wehmeier, de Rougemont, Villard, Ferrari-Lacraz, Golshayan, Gannagé, Binet, Wirthmueller, Sidler, Schachtner, Schaub, Nilsson and the Swiss Transplant Cohort Study

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The impact of the HLA target loci on kidney transplant outcomes in patients with single and multiple DSA. Cumulative incidence of ABMR (A) and death-censored graft survival (B) in patients with a single DSA directed against HLA-A (DSA A), HLA-B (DSA B), HLA-C (DSA C), HLA-DR (DSA DR), HLA-DQ (DSA DQ) and HLA-DP (DSA DP). Cumulative incidence of ABMR (C), death-censored graft survival (D), the collective mean total slope (E), and mean annual slope of eGFR (F) in the patients with combinations of DSA, denoted as mentioned previously. (G) Correlation heat map of kidney transplantation outcome (ABMR, TCMR, and graft loss) DSA characteristics and clinical variables among all investigated patients. Log-rank test was used to test p value of the Kaplan-Meier survival curves for (A–D). One-way ANOVA followed by Dunn’s post hoc test for (E) and two-way ANOVA analysis with Sidak’s multiple comparisons as a post hoc test were used for (F) to assess p values; *p < 0.05, **p < 0.01, ****p < 0.0001.