Table 1.
Characteristics of the recipient and donor in transplants with and without pre-transplant DSA.
| Characteristics | DSA (n = 411) | No DSA (n = 1804) | p value (DSA vs. No DSA) |
|---|---|---|---|
| Female gender (Recipient) | 197 (48%) | 609 (34%) | <0.0001 |
| Age at transplantation (mean value) | 51.7 | 52.8 | 0.04 |
| Female gender (Donor) | 190 (46%) | 934 (52%) | <0.0001 |
| Age (Donor) (mean vlaue) | 51.5 | 52.5 | |
| Previously transplanted | 181 (44%) | 221 (12%) | <0.0001 |
| Previous pregnancy | 45 (23% in female) | 130 (21% in female) | |
| Previous blood transfusion | 204 (50%); 62 (unknown) |
479 (27%); 341 (unknown) |
|
| Immunosuppression | <0.0001 | ||
| FK-MPA-Pred | 354 (86%) | 1364 (77%) | |
| CyA-MPA-Pred | 44 (11%) | 357 (20%) | |
| CNI-based other | 10 (3%) | 19 (1%) | |
| mTOR-containing | 2 (1%) | 48 (3%) | |
| Other | 1 (0%) | 14 (0%) | |
| Induction therapy | <0.0001 | ||
| ATG/Thymo+/- lvlg | 275 (67%) | 274 (16%) | |
| Basiliximab | 135 (33%) | 1473 (81%) | |
| None | 1 (0%) | 57 (3%) | |
| Underlying renal disease | <0.0001 | ||
| Glomerulonephritis | 92 (22%) | 449 (25%) | |
| ADPKD | 75 (18%) | 341 (19%) | |
| Diabetic nephropathy | 28 (7%) | 161 (9%) | |
| Vascular nephropathy | 30 (7%) | 222 (12%) | |
| Interstitial nephropathy | 10 (3%) | 63 (4%) | |
| Other | 100 (24%) | 403 (22%) | |
| Not specified | 58 (14%) | 211 (12%) | |
| Reflux/Pyelonephritis | 18 (4%) | 93 (5%) | |
| Hereditary (not ADPKD) | 11 (3%) | 57 (3%) | |
| Congenital | 13 (3%) | 42 (2%) | |
| Unknown | 76 (19%) | 165 (9%) | |
| HLA mismatch | |||
| A, % with 0/1/2 | 14/47/39 | 16/46/38 | 0.800 |
| B, % with 0/1/2 | 6/41/53 | 9/40/51 | 0.180 |
| DRB1, % with 0/1/2 | 10/56/34 | 18/53/29 | 0.002 |
| Cold ischemia time (DD)/h (mean value) |
9.0 (6.9–12.1) | 9.4 (7.3–12.3) | 0.10 |
| Donor type | |||
| No. of donation (DD/LD) | 294/117 | 1118/686 | <0.0001 |
| Percentage. of donation (DD/LD), % |
71.5/28.5 | 62.0/38.0 | <0.0001 |
| Age donor (DD/LD) (mean value) |
50.7/53.5 | 51.9/53.6 | 0.362 |
| Female gender of donor (DD/LD), % |
42.5/55.6 | 44.2/64.4 | 0.098 |
DD, Disease donation; LD, Living donation.