TABLE 4.
Characteristics of the negative studies regarding the relationship of Klotho with vascular calcification in CKD patients.
| Author | Year | Country | Study design | N | Sample | Age | Disease models | Outcomes | Relationship | NOS |
|---|---|---|---|---|---|---|---|---|---|---|
| Liang | 2021 | China | Observational | 716 | Serum | 53.6 ± 13.5 (men) | General population | BP cfPWV | No | 7 stars |
| 51.0 ± 12.0 (women) | ||||||||||
| Savvoulidis | 2020 | Greece | Observational | 60 | Serum | 63 (52, 72.5) | CKD1-5 | CAC | No | 7 stars |
| AVC | ||||||||||
| Chou | 2019 | Taiwan | Before and after | 62 | Serum | 59 (52–65) | MHD | AAC | No | — |
| Nattero Chávez | 2019 | Spain | Observational | 164 | Plasma | 37 ± 10 | DM | MAC | No | 6 stars |
| Krishnasamy | 2017 | Australia | Prospective | 82 | Serum | 62.9 ± 10.2 | CKD4-5 | AAC | No | 8 stars |
| 42Controls | ||||||||||
| Di Lullo | 2015 | Italy | Observational | 100 | Serum | 51 (46–56) | CKD3-4 | Valve Calcification | No | 5 stars |
| Morita | 2015 | Japan | Observational | 157 | Serum | W:65.8 ± 11.5 | CKD2 | CAC | No | 7 stars |
| M:67.0 ± 11.6 | CKD2 | AVC | No | |||||||
| Buiten | 2014 | United Kingdom | Observational | 127 | Plasma | 67 ± 7 | MHD | AAC | No | 8 stars |
| CAC | No | |||||||||
| Kitagawa | 2013 | Japan | Observational | 114 | Serum | 58 (47–66) | CKD1-3 | ACI | No | 5 stars |
CKD, chronic kidney disease; BP, blood pressure; cfPWV, carotid–femoral pulse wave velocity; MHD, maintenance hemodialysis; W, women; M, men; MAC, medial arterial calcification; CAC, coronary artery calcification; AVC, aortic valve calcification; AAC, abdominal aorta calcification; ACI, aortic calcification index