Table 5.
Mechanisms associated with phytoestrogen treatment with AD.
| TCM | Methods | Animal | Cell | Mechanism | Reference |
|---|---|---|---|---|---|
| Curcumin | / | / | SH-SY5Y HEK293- APPswe |
ERβ↑/NFκB↓ Aβ↓、BACE1↓ |
(176) Huang P,et al.2020 |
| Resveratrol | SAMP8 | Mice | / | ERα/ERβ↑、Nrf2/HO-1↑Aβ↓ | (182) Kong D,et al.2019 |
| Genistein | Aβ25-35 | / | PRHN | GluR2↑、NR2B↑ | (185) Wang Yxiang,et al.2020 |
| Kaempferol | Aβ25-35 | / | PC-12 | ER/ERK | (180) Zhang N,et al.2020 |
| Biochanin A | APP/PS1 OVX |
Mice | / | Beclin1、LC3B↑ p-Drp1、OPA1、Mfn2↑ Aβ↓、BACE1↓ |
(183) Hou Y,et al.2022 |
| Patchouli alcohol | APP/PS1 PTA |
Mice | BV2 | ERβ/BDNF/TrkB/CREB | (181) Yan Qying,et al.2022 |
| α-ZAL | Aβ25-35 | / | PRHN | GRP78/PERK/CHOP10↓ | (184) Yilong D,et al.2017 |
| Calycosin | APP/PS1 | Mice | / | PKC | (177) Song L,et al.2017 |
| Silibinin | Aβ1−42 | Rats | / | ERER↓/PI3K↓/Akt↓ p-JNK↑ p-p38/p-ERK↓ |
(178) Xiaoyu S,et al.2018 |
| Erzhi pills | OVXd-gal Aβ1-40 |
Rats | / | PI3K↑/Akt↑/GSK3β↓ Bad/Bcl-xl/Bcl-2↑ Aβ↓、p-Tau↓ |
(179) XieY,et al.2021 |
OVX, Ovariectomize.
The '↑' means up-regulation and '↓' means down-regulation.