Table 2.
Number of stage III colorectal cancer patients and percentage point difference of rate for receiving adjuvant chemotherapy between the presence and absence of pre‐existing diabetes mellitus
| Without DM (n = 5,078) | With DM (n = 1,266) | Difference in rate between patients without and with DM, percentage points (95% CI) | |||||
|---|---|---|---|---|---|---|---|
| Received/not received (n) | Rate of adjuvant chemotherapy (%) | Received/not received (n) | Rate of adjuvant chemotherapy (%) | Crude | Adjusted † | Adjusted ‡ | |
| All (n = 6,344) | 2,993/2,085 | 58.9 | 631/635 | 49.8 | 9.1 (6.0, 12.2) | 4.6 (1.7, 7.5) | 3.9 (1.0, 6.8) |
| Age group stratification | |||||||
| <60 years (n = 1,274) | 849/278 | 75.3 | 101/46 | 68.7 | 6.6 (−1.3, 14.5) | 7.7 (−0.4, 15.6) | 7.4 (−0.5, 15.4) |
| 60–69 years (n = 1,876) | 1,093/406 | 72.9 | 240/137 | 63.7 | 9.3 (3.9, 14.6) | 8.9 (3.7, 14.2) | 7.5 (2.3, 12.7) |
| 70–79 years (n = 2,110) | 917/687 | 57.2 | 252/254 | 49.8 | 7.4 (2.4, 12.4) | 7.8 (2.9, 12.8) | 7.2 (2.2, 12.2) |
| ≥80 years (n = 1,084) | 134/714 | 15.8 | 38/198 | 16.1 | −0.3 (−5.6, 5.0) | 0.2 (−5.1, 5.4) | −0.3 (−5.5, 4.9) |
| Stratification of non‐DM comorbidities | |||||||
| No any comorbidity (n = 4,212) | 2,130/1,297 | 62.2 | 423/362 | 53.9 | 8.3 (4.4, 12.1) | 4.3 (0.6, 8.0) | 3.3 (−0.3, 7.0) |
| Any comorbidity (n = 2,132) | 863/788 | 52.2 | 208/273 | 43.2 | 9.0 (4.0, 14.1) | 4.4 (−0.2, 9.1) | 4.1 (−0.6, 8.7) |
†
Adjusted for age (excluding analysis for age group stratification), sex, Charlson Comorbidity Index, type of hospital (Designated Cancer Care Hospitals or others) and prefecture where hospitals are located using the multilevel generalized linear model.
‡
Additionally adjusted for the absence or presence of postoperative complications.
CI, confidence interval; CRC, colorectal cancer; DM, diabetes mellitus.