Table 3.
Model comparison of the explained variances of the subclinical psychosis dimensions
| Explained variance by the models (R2) (%) | PRS-SZ | LRT: comparison of ‘G’ and ‘E + G’ models (p-values) | Environmental factor | LRT: comparison of ‘E’ and ‘E + G’ models (p-values) | Interaction term between the PRS-SZ and the environmental factor | LRT: comparison of ‘E + G’ and ‘E + G + E × G’ models (p-values) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| β | s.d. | p-value | β | s.d. | p-value | β | s.d. | p-value | |||||||
| Positive dimension | G | 7.77 | 0.086 | 0.037 | 0.024 | – | – | – | – | – | – | – | – | – | |
| Self-reported discrimination experiences | E | 8.53 | – | – | – | – | 0.122 | 0.037 | 0.001 | – | – | – | – | – | |
| E + G | 9.26 | 0.085 | 0.037 | 0.026 | 0.006 | 0.122 | 0.037 | 0.001 | 0.013 | – | – | – | – | ||
| E + G + E × G | 9.28 | 0.085 | 0.037 | 0.026 | – | 0.127 | 0.038 | 0.001 | – | 0.006 | 0.037 | 0.776 | 0.884 | ||
| Childhood trauma | E | 11.00 | – | – | – | – | 0.199 | 0.036 | <0.001 | – | – | – | – | – | |
| E + G | 11.49 | 0.069 | 0.036 | 0.065 | <0.001 | 0.193 | 0.036 | <0.001 | 0.041 | – | – | – | – | ||
| E + G + E × G | 11.49 | 0.069 | 0.036 | 0.065 | – | 0.192 | 0.037 | <0.001 | – | 0.004 | 0.036 | 0.887 | 0.937 | ||
| Stressful life events | E | 9.64 | – | – | – | – | 0.162 | 0.036 | <0.001 | – | – | – | – | – | |
| E + G | 10.24 | 0.076 | 0.036 | 0.044 | <0.001 | 0.157 | 0.036 | <0.001 | 0.037 | – | – | – | – | ||
| E + G + E × G | 10.27 | 0.076 | 0.037 | 0.045 | – | 0.157 | 0.037 | <0.001 | – | −0.007 | 0.037 | 0.714 | 0.652 | ||
| Low level of social capital | E | 7.50 | – | – | – | – | 0.069 | 0.037 | 0.087 | – | – | – | – | – | |
| E + G | 8.26 | 0.086 | 0.037 | 0.024 | 0.066 | 0.068 | 0.037 | 0.088 | 0.013 | – | – | – | – | ||
| E + G + E × G | 8.37 | 0.085 | 0.037 | 0.026 | – | 0.066 | 0.037 | 0.101 | – | −0.029 | 0.036 | 0.470 | 0.650 | ||
| Negative dimension | G | 4.17 | 0.014 | 0.038 | 0.718 | – | – | – | – | – | – | – | – | – | |
| Self-reported discrimination experiences | E | 5.71 | – | – | – | – | 0.125 | 0.037 | 0.001 | – | – | – | – | – | |
| E + G | 5.73 | 0.012 | 0.037 | 0.748 | <0.001 | 0.125 | 0.037 | 0.001 | 0.910 | – | – | – | – | ||
| E + G + E × G | 5.75 | 0.012 | 0.037 | 0.747 | – | 0.125 | 0.037 | 0.001 | – | −0.012 | 0.038 | 0.740 | 0.777 | ||
| Childhood trauma | E | 8.13 | – | – | – | – | 0.200 | 0.037 | <0.001 | – | – | – | – | – | |
| E + G | 8.14 | −0.004 | 0.037 | 0.854 | <0.001 | 0.200 | 0.037 | <0.001 | 0.723 | – | – | – | – | ||
| E + G + E × G | 8.48 | −0.006 | 0.037 | 0.838 | – | 0.213 | 0.038 | <0.001 | – | −0.057 | 0.036 | 0.125 | 0.188 | ||
| Stressful life events | E | 5.54 | – | – | – | – | 0.117 | 0.037 | 0.007 | – | – | – | – | – | |
| E + G | 5.55 | 0.006 | 0.038 | 0.830 | <0.001 | 0.117 | 0.037 | 0.007 | 0.883 | – | – | – | – | ||
| E + G + E × G | 5.70 | 0.005 | 0.038 | 0.835 | – | 0.118 | 0.037 | 0.006 | – | −0.035 | 0.038 | 0.386 | 0.304 | ||
| Low level of social capital | E | 5.38 | – | – | – | – | 0.110 | 0.037 | 0.008 | – | – | – | – | – | |
| E + G | 5.40 | 0.014 | 0.037 | 0.723 | <0.001 | 0.109 | 0.037 | 0.009 | 0.897 | – | – | – | – | ||
| E + G + E × G | 5.44 | 0.014 | 0.037 | 0.712 | – | 0.111 | 0.037 | 0.008 | – | 0.016 | 0.037 | 0.660 | 0.870 | ||
| Depressive dimension | G | 6.10 | 0.036 | 0.037 | 0.350 | – | – | – | – | – | – | – | – | – | |
| Self-reported discrimination experiences | E | 7.47 | – | – | – | – | 0.122 | 0.037 | 0.001 | – | – | – | – | – | |
| E + G | 7.59 | 0.034 | 0.037 | 0.369 | <0.001 | 0.122 | 0.037 | 0.001 | 0.373 | – | – | – | – | ||
| E + G + E × G | 7.62 | 0.034 | 0.037 | 0.369 | – | 0.123 | 0.037 | 0.001 | – | −0.017 | 0.038 | 0.656 | 0.489 | ||
| Childhood trauma | E | 9.21 | – | – | – | – | 0.180 | 0.037 | <0.001 | – | – | – | – | – | |
| E + G | 9.26 | 0.018 | 0.037 | 0.595 | <0.001 | 0.178 | 0.037 | <0.001 | 0.611 | – | – | – | – | ||
| E + G + E × G | 9.59 | 0.022 | 0.037 | 0.566 | – | 0.165 | 0.038 | <0.001 | – | 0.056 | 0.036 | 0.124 | 0.058 | ||
| Stressful life events | E | 9.30 | – | – | – | – | 0.181 | 0.037 | <0.001 | – | – | – | – | – | |
| E + G | 9.36 | 0.024 | 0.036 | 0.525 | <0.001 | 0.180 | 0.037 | <0.001 | 0.604 | – | – | – | – | ||
| E + G + E × G | 9.59 | 0.022 | 0.037 | 0.559 | – | 0.182 | 0.037 | <0.001 | – | −0.047 | 0.037 | 0.239 | 0.325 | ||
| Low level of social capital | E | 7.33 | – | – | – | – | 0.115 | 0.037 | 0.004 | – | – | – | – | – | |
| E + G | 7.46 | 0.035 | 0.037 | 0.354 | 0.014 | 0.115 | 0.037 | 0.004 | 0.363 | – | – | – | – | ||
| E + G + E × G | 7.58 | 0.036 | 0.037 | 0.338 | – | 0.118 | 0.037 | 0.004 | – | 0.032 | 0.037 | 0.408 | 0.337 | ||
E, Environmental model; E + G, Independent model; E + G + E × G, Interaction model; G, Genetic model; LRT, Likelihood ratio test; PRS-SZ, polygenic risk score for schizophrenia.
The different models were adjusted on age, sex, and the first ten principal components of the ethnicity-based genetic variance.
The significant associations are shown in bold.