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. 2022 Sep 20;13:977235. doi: 10.3389/fimmu.2022.977235

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Copyright © 2022 Li, Ma, Li, Zheng, Wang, Chen, Wang, Ge, Qin, Zheng, Deng and Zeng

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Lung CD11b⁺ trained macrophages undergo metabolic reprogramming. (A) Heat map of differential metabolites of PVM-OVA group vs PBS group. (B) Venn plot of the numbers of different metabolites among groups. The diagram shows overlapping and distinct metabolites indicated by the numbers in the intersections and circles, respectively. (C) KEGG compound classification of differential metabolites. (D) Heat maps of differential metabolite amino acids or phospholipids. (E) KEGG pathway enrichment analysis. (F) The abundance of metabolites related to TCA cycle. ***P<0.001, ****P<0.0001.