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. 2022 Sep 20;13:977235. doi: 10.3389/fimmu.2022.977235

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Copyright © 2022 Li, Ma, Li, Zheng, Wang, Chen, Wang, Ge, Qin, Zheng, Deng and Zeng

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Proline metabolism in mice sensitized with PVM-OVA was significantly reprogrammed. (A) Volcanic map of differential metabolites of PVM-OVA group vs PBS group. (B) The abundance of proline. (C) Diagram of proline synthesis pathway from glutamine. (D) The abundance of dipeptide containing glutamic acid. (E) Relative expression of enzymes, GLS1, GLS2 and PYCR1, in the synthesis pathway of proline in the lung by real-time PCR. Each experimental group contained three biology repeats. *P<0.05, ***P<0.001, ****P<0.0001.