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Graphical representation of results. (A, B) Neonatal respiratory virus infection can promote the occurrence of non-Th2 allergic asthma through the production of a large number of trained macrophages, which undergo metabolic reprogramming. (C, D) Notably, proline metabolic reprogramming mediate development of the trained macrophages as well as non-Th2 allergic asthma in childhood mice.
