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. 2022 Sep 12;13:990015. doi: 10.3389/fgene.2022.990015

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Copyright © 2022 Park, Jang, Lee, Kim, Sim, Jeon, Hong, Lee, Lee, Jeon, Lee, Lee, Kim, Kim, Yoon, Lim, Kim, Kim, Ko, Cho, Lee, Choi and Chae.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparison of genetic characteristics of genes and variants that follow dominant or recessive inheritance. (A) Comparison of pLI or O/E scores of NDD causal genes across inheritance patterns. (B) Comparison of functional (CADD, SIFT, and phyloP) and conservation scores among NDD causal variants according to inheritance patterns. “AA conservation” denotes the number of species with different amino acids in 99 human ortholog proteins. *, p-value < 0.1, **, p-value < 0.01, ***, p-value < 0.001. ****, p-value < 0.00001.