Table 24.
Hazard Ratios for Death and 95% Confidence Intervals for Age Group at Diagnosis, Sex, Race, and Ethnicity for Selected Primary Malignant Brain and Other Central Nervous System Tumor Histopathologies, CBTRUS Statistical Report: NPCR, 2001-2018 (varying)
| Histopathology | N | Deaths | Age Groupsa | Sexb | Race & Ethnicityc | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 15-39 Yearsd | 40+ Years | Female | Black, Non-Hispanic | AIAN, Non-Hispanic | API, Non-Hispanic | Hispanic | ||||||||||
| HR (95% CI) | P-value | HR (95% CI) | P-value | HR (95% CI) | P-value | HR (95% CI) | P-value | HR (95% CI) | P-value | HR (95% CI) | P-value | HR (95% CI) | P-value | |||
| Diffuse astrocytoma | 25,047 | 13,802 | 1.89 (1.72-2.08) | <0.0001 | 6.77 (6.19-7.40) | <0.0001 | 0.96 (0.93-0.99) | 0.0132 | 1.04 (0.97-1.11) | 0.2563 | 0.81 (0.66-1.01) | 0.0583 | 0.88 (0.78-0.98) | 0.0194 | 0.79 (0.75-0.84) | <0.0001 |
| Anaplastic astrocytoma | 17,821 | 12,453 | 0.39 (0.35-0.43) | <0.0001 | 1.28 (1.18-1.40) | <0.0001 | 0.97 (0.93-1.00) | 0.0495 | 1.08 (1.00-1.15) | 0.0444 | 0.91 (0.71-1.16) | 0.4344 | 0.85 (0.76-0.95) | 0.0050 | 0.81 (0.76-0.86) | <0.0001 |
| Glioblastoma | 145,178 | 129,570 | 0.73 (0.68-0.78) | <0.0001 | 1.77 (1.66-1.89) | <0.0001 | 1.02 (1.01-1.03) | <0.0001 | 0.92 (0.90-0.94) | <0.0001 | 1.01 (0.93-1.11) | 0.7750 | 0.70 (0.67-0.73) | <0.0001 | 0.77 (0.75-0.78) | <0.0001 |
| Oligodendroglioma | 11,989 | 3,722 | 3.44 (2.36-5.01) | <0.0001 | 7.59 (5.23-11.03) | <0.0001 | 0.86 (0.81-0.92) | <0.0001 | 1.39 (1.21-1.59) | <0.0001 | 1.28 (0.87-1.90) | 0.2144 | 0.79 (0.64-0.97) | 0.0273 | 0.76 (0.68-0.86) | <0.0001 |
| Anaplastic oligodendroglioma | 5,351 | 2,532 | 0.74 (0.49-1.11) | 0.1410 | 1.57 (1.05-2.33) | 0.0261 | 0.89 (0.82-0.96) | 0.0031 | 1.24 (1.06-1.46) | 0.0089 | 0.91 (0.53-1.57) | 0.7405 | 0.78 (0.64-0.96) | 0.0192 | 0.79 (0.69-0.90) | 0.0007 |
| Oligoastrocytic tumors | 6,941 | 3,503 | 1.74 (1.29-2.35) | 0.0003 | 3.68 (2.74-4.94) | <0.0001 | 0.92 (0.86-0.98) | 0.0123 | 1.34 (1.17-1.53) | <0.0001 | 1.29 (0.87-1.89) | 0.2026 | 0.90 (0.74-1.09) | 0.2899 | 0.85 (0.75-0.95) | 0.0060 |
| Pilocytic astrocytoma | 15,813 | 1,197 | 1.81 (1.57-2.09) | <0.0001 | 8.32 (7.25-9.54) | <0.0001 | 0.85 (0.76-0.96) | 0.0064 | 1.35 (1.13-1.61) | 0.0008 | 1.25 (0.67-2.34) | 0.4786 | 0.85 (0.57-1.28) | 0.4398 | 1.09 (0.91-1.29) | 0.3409 |
| Unique astrocytoma variants | 2,463 | 420 | 2.13 (1.63-2.79) | <0.0001 | 7.94 (6.06-10.39) | <0.0001 | 0.78 (0.64-0.94) | 0.0106 | 0.84 (0.62-1.13) | 0.2410 | 1.06 (0.44-2.57) | 0.8927 | 1.10 (0.68-1.80) | 0.6919 | 0.83 (0.62-1.11) | 0.2007 |
| Ependymal tumors | 18,710 | 3,277 | 0.33 (0.29-0.37) | <0.0001 | 0.86 (0.79-0.94) | 0.0007 | 0.78 (0.73-0.84) | <0.0001 | 1.43 (1.27-1.60) | <0.0001 | 1.28 (0.86-1.90) | 0.2219 | 0.78 (0.61-0.99) | 0.0446 | 1.12 (1.01-1.24) | 0.0256 |
| Glioma malignant, NOS | 20,825 | 9,875 | 0.77 (0.71-0.83) | <0.0001 | 3.52 (3.35-3.69) | <0.0001 | 1.01 (0.97-1.05) | 0.7423 | 1.07 (1.00-1.14) | 0.0387 | 0.91 (0.69-1.20) | 0.5096 | 0.91 (0.81-1.02) | 0.1059 | 0.99 (0.93-1.06) | 0.8101 |
| Choroid plexus tumors | 2,274 | 338 | 0.55 (0.39-0.79) | 0.0011 | 2.41 (1.90-3.07) | <0.0001 | 0.89 (0.71-1.10) | 0.2744 | 1.74 (1.24-2.44) | 0.0012 | 2.03 (0.84-4.95) | 0.1171 | 1.38 (0.80-2.37) | 0.2458 | 0.93 (0.68-1.27) | 0.6420 |
| Other neuroepithelial tumors | 283 | 83 | 2.46 (0.80-7.53) | 0.1146 | 13.18 (4.75-36.56) | <0.0001 | 0.96 (0.60-1.52) | 0.8489 | 0.76 (0.34-1.70) | 0.5064 | ** (**-**) | ** | 0.83 (0.26-2.66) | 0.7502 | 0.85 (0.43-1.68) | 0.6362 |
| Neuronal and mixed neuronal-glial tumors | 12,602 | 1,559 | 1.43 (1.18-1.73) | 0.0002 | 6.04 (5.10-7.15) | <0.0001 | 0.78 (0.70-0.86) | <0.0001 | 1.49 (1.28-1.73) | <0.0001 | 1.80 (1.04-3.11) | 0.0357 | 1.09 (0.82-1.44) | 0.5538 | 1.15 (0.98-1.35) | 0.0826 |
| Tumors of the pineal region | 1,979 | 506 | 0.55 (0.43-0.70) | <0.0001 | 1.04 (0.83-1.30) | 0.7328 | 0.57 (0.47-0.68) | <0.0001 | 1.28 (1.02-1.61) | 0.0356 | 1.00 (0.41-2.43) | 0.9990 | 0.54 (0.25-1.14) | 0.1061 | 1.13 (0.88-1.45) | 0.3441 |
| Embryonal tumors | 10,715 | 4,194 | 0.83 (0.77-0.90) | <0.0001 | 1.96 (1.79-2.15) | <0.0001 | 1.00 (0.94-1.06) | 0.9695 | 1.20 (1.09-1.32) | 0.0002 | 0.71 (0.46-1.08) | 0.1053 | 1.02 (0.87-1.20) | 0.7888 | 0.96 (0.89-1.04) | 0.2917 |
| Nerve sheath tumors | 87,503 | 8,450 | 1.58 (1.19-2.10) | 0.0018 | 6.11 (4.66-8.01) | <0.0001 | 0.84 (0.81-0.88) | <0.0001 | 1.18 (1.08-1.29) | 0.0003 | 1.44 (1.12-1.86) | 0.0045 | 0.60 (0.53-0.69) | <0.0001 | 0.84 (0.77-0.91) | <0.0001 |
| Other tumors of cranial and spinal nerves | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Meningiomas | 382,599 | 107,072 | 0.80 (0.60-1.06) | 0.1178 | 5.75 (4.34-7.60) | <0.0001 | 0.70 (0.69-0.71) | <0.0001 | 1.03 (1.01-1.04) | 0.0080 | 0.80 (0.73-0.88) | <0.0001 | 0.63 (0.61-0.66) | <0.0001 | 0.71 (0.69-0.73) | <0.0001 |
| Mesenchymal tumors | 16,764 | 2,943 | 0.86 (0.68-1.08) | 0.1984 | 3.10 (2.52-3.82) | <0.0001 | 0.87 (0.81-0.94) | 0.0002 | 1.19 (1.06-1.34) | 0.0036 | 1.03 (0.71-1.50) | 0.8602 | 0.76 (0.60-0.96) | 0.0194 | 0.93 (0.82-1.05) | 0.2303 |
| Primary melanocytic lesions | 281 | 174 | 0.35 (0.18-0.67) | 0.0015 | 0.75 (0.43-1.30) | 0.3076 | 0.94 (0.69-1.28) | 0.6898 | 1.09 (0.56-2.15) | 0.7966 | ** (**-**) | ** | 0.98 (0.31-3.11) | 0.9780 | 1.00 (0.62-1.59) | 0.9860 |
| Lymphoma | 19,855 | 13,519 | 3.64 (2.56-5.18) | <0.0001 | 6.93 (4.90-9.81) | <0.0001 | 0.94 (0.91-0.97) | 0.0002 | 1.15 (1.08-1.22) | <0.0001 | 1.06 (0.85-1.32) | 0.6138 | 0.79 (0.73-0.86) | <0.0001 | 0.88 (0.84-0.94) | <0.0001 |
| Other hematopoietic neoplasms | 209 | 97 | ** (**-**) | ** | ** (**-**) | ** | 1.02 (0.68-1.54) | 0.9174 | 0.81 (0.49-1.35) | 0.4276 | 1.84 (0.44-7.65) | 0.4009 | 1.11 (0.40-3.08) | 0.8393 | 0.72 (0.37-1.38) | 0.3193 |
| Germ cell tumors | 3,569 | 518 | 1.00 (0.83-1.21) | 0.9997 | 2.08 (1.55-2.78) | <0.0001 | 1.30 (1.08-1.58) | 0.0069 | 0.87 (0.63-1.21) | 0.4191 | 1.59 (0.59-4.27) | 0.3558 | 1.03 (0.76-1.41) | 0.8313 | 1.08 (0.87-1.33) | 0.4991 |
| Tumors of the pituitary | 172,615 | 20,558 | 2.04 (1.30-3.22) | 0.0021 | 20.62 (13.15-32.33) | <0.0001 | 0.75 (0.73-0.77) | <0.0001 | 1.14 (1.10-1.18) | <0.0001 | 0.91 (0.76-1.08) | 0.2737 | 0.63 (0.58-0.69) | <0.0001 | 0.71 (0.68-0.75) | <0.0001 |
| Craniopharyngioma | 8,005 | 1,673 | 1.99 (1.58-2.50) | <0.0001 | 6.61 (5.43-8.05) | <0.0001 | 0.86 (0.78-0.95) | 0.0028 | 1.73 (1.55-1.93) | <0.0001 | 1.54 (0.94-2.53) | 0.0863 | 0.63 (0.46-0.85) | 0.0030 | 1.03 (0.88-1.20) | 0.7045 |
| Hemangioma | 8,709 | 957 | 1.49 (0.76-2.89) | 0.2436 | 11.15 (5.98-20.82) | <0.0001 | 0.65 (0.57-0.73) | <0.0001 | 1.45 (1.20-1.76) | 0.0001 | ** (**-**) | ** | 0.64 (0.44-0.95) | 0.0252 | 0.80 (0.65-0.99) | 0.0426 |
| Neoplasm, unspecified | 28,825 | 15,949 | 0.73 (0.63-0.85) | <0.0001 | 5.53 (4.87-6.29) | <0.0001 | 0.94 (0.91-0.97) | <0.0001 | 0.74 (0.70-0.78) | <0.0001 | 0.71 (0.57-0.88) | 0.0019 | 0.80 (0.72-0.89) | <0.0001 | 0.64 (0.61-0.68) | <0.0001 |
| All other | 1,260 | 206 | 1.53 (0.78-3.03) | 0.2182 | 9.22 (5.23-16.26) | <0.0001 | 0.67 (0.51-0.89) | 0.0057 | 1.11 (0.71-1.72) | 0.6452 | 3.36 (0.83-13.61) | 0.0901 | 0.49 (0.16-1.54) | 0.2223 | 0.95 (0.64-1.41) | 0.8008 |
Reference group is Children (<14 years) as defined by the National Cancer Institute, see: http://www.cancer.gov/researchandfunding/snapshots/pediatric.
Reference group is males.
Reference group is White non-Hispanic.
Adolescents and Young Adults (AYA), as defined by the National Cancer Institute, see: http://www.cancer.gov/cancertopics/aya.
** Cannot be calculated.
-- Survival estimates are not presented when fewer than 100 cases were reported for the specific category.
Abbreviations: AIAN, American Indian/Alaska Native; API, Asian or Pacific Islander; CBTRUS, Central Brain Tumor Registry of the United States; CI, confidence interval; HR: Hazard Ratio; NOS, not otherwise specified; NPCR, National Program of Cancer Registries; SEER, Surveillance, Epidemiology, and End Results Program.