Table 4.
Five-Year Total, Annual Average Totala, and Average Annual Age-Adjusted Incidence Ratesb with 95% Confidence Intervals of All Brain and Other Central Nervous System Tumors by Sitec and Sex, CBTRUS Statistical Report: US Cancer Statistics – NPCR and SEER, 2015-2019
| Site (ICD-O Topography Code) | Total | Male | Female | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 5-Year Total | Annual Average | % of all tumors | Rate (95% CI) | 5-Year Total | Annual Average | % of all tumors | Rate (95% CI) | 5-Year Total | Annual Average | % of all tumors | Rate (95% CI) | |
| Olfactory tumors of the nasal cavity (C30.0)d | 735 | 147 | 0.2% | 0.04 (0.04-0.04) | 419 | 84 | 0.2% | 0.05 (0.04-0.05) | 316 | 63 | 0.1% | 0.03 (0.03-0.04) |
| Meninges (cerebral and spinal) (C70.0-C70.9) | 179,112 | 35,822 | 40.2% | 9.55 (9.50-9.59) | 48,792 | 9,758 | 26.5% | 5.69 (5.64-5.75) | 130,320 | 26,064 | 49.8% | 12.97 (12.90-13.04) |
| Cerebral meninges (C70.0) | 147,043 | 29,409 | 33.0% | 7.84 (7.80-7.88) | 40,373 | 8,075 | 21.9% | 4.71 (4.66-4.76) | 106,670 | 21,334 | 40.8% | 10.62 (10.56-10.69) |
| Spinal meninges (C70.1) | 7,591 | 1,518 | 1.7% | 0.40 (0.39-0.41) | 1,662 | 332 | 0.9% | 0.19 (0.18-0.20) | 5,929 | 1,186 | 2.3% | 0.58 (0.57-0.60) |
| Meninges, NOS (C70.9) | 24,478 | 4,896 | 5.5% | 1.31 (1.29-1.33) | 6,757 | 1,351 | 3.7% | 0.79 (0.77-0.81) | 17,721 | 3,544 | 6.8% | 1.77 (1.74-1.80) |
| Cerebrum (C71.0) | 7,460 | 1,492 | 1.7% | 0.43 (0.42-0.44) | 3,978 | 796 | 2.2% | 0.47 (0.46-0.49) | 3,482 | 696 | 1.3% | 0.39 (0.37-0.40) |
| Frontal, temporal, parietal, and occipital lobes of the brain (C71.1-C71.4) | 76,878 | 15,376 | 17.2% | 4.20 (4.17-4.23) | 43,063 | 8,613 | 23.4% | 4.96 (4.92-5.01) | 33,815 | 6,763 | 12.9% | 3.52 (3.49-3.56) |
| Frontal lobe (C71.1) | 33,973 | 6,795 | 7.6% | 1.88 (1.86-1.90) | 18,138 | 3,628 | 9.8% | 2.12 (2.09-2.15) | 15,835 | 3,167 | 6.1% | 1.67 (1.65-1.70) |
| Temporal lobe (C71.2) | 24,837 | 4,967 | 5.6% | 1.35 (1.33-1.36) | 14,876 | 2,975 | 8.1% | 1.70 (1.68-1.73) | 9,961 | 1,992 | 3.8% | 1.03 (1.01-1.06) |
| Parietal lobe (C71.3) | 14,252 | 2,850 | 3.2% | 0.76 (0.75-0.77) | 7,945 | 1,589 | 4.3% | 0.90 (0.88-0.92) | 6,307 | 1,261 | 2.4% | 0.64 (0.62-0.66) |
| Occipital lobe (C71.4) | 3,816 | 763 | 0.9% | 0.21 (0.20-0.21) | 2,104 | 421 | 1.1% | 0.24 (0.23-0.25) | 1,712 | 342 | 0.7% | 0.18 (0.17-0.18) |
| Ventricle (C71.5) | 4,109 | 822 | 0.9% | 0.25 (0.24-0.26) | 2,279 | 456 | 1.2% | 0.28 (0.27-0.29) | 1,830 | 366 | 0.7% | 0.22 (0.21-0.23) |
| Cerebellum (C71.6) | 9,291 | 1,858 | 2.1% | 0.58 (0.57-0.59) | 5,028 | 1,006 | 2.7% | 0.64 (0.62-0.65) | 4,263 | 853 | 1.6% | 0.52 (0.51-0.54) |
| Brain stem (C71.7) | 6,113 | 1,223 | 1.4% | 0.39 (0.38-0.40) | 3,284 | 657 | 1.8% | 0.42 (0.40-0.43) | 2,829 | 566 | 1.1% | 0.36 (0.35-0.38) |
| Other brain (C71.8-C71.9) | 33,701 | 6,740 | 7.6% | 1.84 (1.82-1.86) | 18,023 | 3,605 | 9.8% | 2.11 (2.08-2.15) | 15,678 | 3,136 | 6.0% | 1.61 (1.59-1.64) |
| Overlapping lesion of brain (C71.8) | 12,794 | 2,559 | 2.9% | 0.69 (0.68-0.70) | 7,210 | 1,442 | 3.9% | 0.83 (0.81-0.85) | 5,584 | 1,117 | 2.1% | 0.57 (0.55-0.58) |
| Brain, NOS (C71.9) | 20,907 | 4,181 | 4.7% | 1.16 (1.14-1.17) | 10,813 | 2,163 | 5.9% | 1.29 (1.26-1.31) | 10,094 | 2,019 | 3.9% | 1.04 (1.02-1.07) |
| Spinal cord and cauda equina (C72.0-C72.1) | 12,700 | 2,540 | 2.8% | 0.74 (0.73-0.76) | 6,761 | 1,352 | 3.7% | 0.81 (0.79-0.83) | 5,939 | 1,188 | 2.3% | 0.68 (0.66-0.70) |
| Spinal cord (C72.0) | 12,303 | 2,461 | 2.8% | 0.72 (0.71-0.73) | 6,560 | 1,312 | 3.6% | 0.79 (0.77-0.81) | 5,743 | 1,149 | 2.2% | 0.66 (0.64-0.68) |
| Cauda equina (C72.1) | 397 | 79 | 0.1% | 0.02 (0.02-0.03) | 201 | 40 | 0.1% | 0.02 (0.02-0.03) | 196 | 39 | 0.1% | 0.02 (0.02-0.03) |
| Cranial nerves (C72.2-C72.5) | 30,488 | 6,098 | 6.8% | 1.69 (1.67-1.71) | 14,307 | 2,861 | 7.8% | 1.65 (1.62-1.68) | 16,181 | 3,236 | 6.2% | 1.74 (1.71-1.76) |
| Olfactory nerve (C72.2) | 42 | 8 | 0.0% | 0.00 (0.00-0.00) | 17 | 3 | 0.0% | 0.00 (0.00-0.00) | 25 | 5 | 0.0% | 0.00 (0.00-0.00) |
| Optic nerve (C72.3) | 1,782 | 356 | 0.4% | 0.12 (0.12-0.13) | 859 | 172 | 0.5% | 0.12 (0.11-0.12) | 923 | 185 | 0.4% | 0.13 (0.12-0.13) |
| Acoustic nerve (C72.4) | 22,509 | 4,502 | 5.0% | 1.22 (1.21-1.24) | 10,581 | 2,116 | 5.7% | 1.20 (1.18-1.23) | 11,928 | 2,386 | 4.6% | 1.25 (1.23-1.27) |
| Cranial nerve, NOS (C72.5) | 6,155 | 1,231 | 1.4% | 0.34 (0.34-0.35) | 2,850 | 570 | 1.5% | 0.33 (0.32-0.34) | 3,305 | 661 | 1.3% | 0.36 (0.35-0.37) |
| Other nervous system (C72.8-C72.9) | 2,506 | 501 | 0.6% | 0.14 (0.13-0.15) | 1,266 | 253 | 0.7% | 0.15 (0.14-0.16) | 1,240 | 248 | 0.5% | 0.13 (0.13-0.14) |
| Overlapping lesion of brain & CNS (C72.8) | 348 | 70 | 0.1% | 0.02 (0.02-0.02) | 188 | 38 | 0.1% | 0.02 (0.02-0.03) | 160 | 32 | 0.1% | 0.02 (0.01-0.02) |
| Nervous system, NOS (C72.9) | 2,158 | 432 | 0.5% | 0.12 (0.12-0.13) | 1,078 | 216 | 0.6% | 0.13 (0.12-0.14) | 1,080 | 216 | 0.4% | 0.12 (0.11-0.12) |
| Pituitary and craniopharyngeal duct (C75.1- C75.2) | 81,005 | 16,201 | 18.2% | 4.74 (4.71-4.78) | 35,971 | 7,194 | 19.5% | 4.23 (4.18-4.27) | 45,034 | 9,007 | 17.2% | 5.35 (5.30-5.40) |
| Pituitary gland (C75.1) | 78,859 | 15,772 | 17.7% | 4.62 (4.58-4.65) | 34,845 | 6,969 | 18.9% | 4.09 (4.05-4.13) | 44,014 | 8,803 | 16.8% | 5.23 (5.18-5.28) |
| Craniopharyngeal duct (C75.2) | 2,146 | 429 | 0.5% | 0.13 (0.12-0.14) | 1,126 | 225 | 0.6% | 0.14 (0.13-0.15) | 1,020 | 204 | 0.4% | 0.12 (0.11-0.13) |
| Pineal (C75.3) | 1,694 | 339 | 0.4% | 0.11 (0.10-0.11) | 997 | 199 | 0.5% | 0.13 (0.12-0.14) | 697 | 139 | 0.3% | 0.09 (0.08-0.09) |
| TOTAL | 445,792 | 89,158 | 100.0% | 24.71 (24.63-24.78) | 184,168 | 36,834 | 100.0% | 21.60 (21.50-21.70) | 261,624 | 52,325 | 100.0% | 27.62 (27.51-27.73) |
aAnnual average cases are calculated by dividing the five-year total by five.
bRates are per 100,000 and are age-adjusted to the 2000 US standard population.
cThe sites referred to in this table are loosely based on the categories and site codes defined in the SEER site/histopathology validation list.
dICD-O-3 histopathology codes 9522-9523 only.
- Counts and rates are not presented when fewer than 16 cases were reported for the specific category. The suppressed cases are included in the counts and rates for totals.
Abbreviations: CBTRUS, Central Brain Tumor Registry of the United States; US, United States; NPCR, National Program of Cancer Registries; SEER, Surveillance, Epidemiology, and End Results Program; CI, confidence interval; NOS, Not otherwise specified.