Table 5.
Five-Year Total, Annual Average Totala, and Average Annual Age-Adjusted Incidence Ratesb with 95% Confidence Intervals for All Brain and Other Central Nervous System Tumors by Major Histopathology Groupings, Histopathology, Behavior, and Sex, CBTRUS Statistical Report: US Cancer Statistics – NPCR and SEER, 2015-2019
| Histopathology | Total | Male | Female | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 5-Year Total | Annual Average | % of all tumors | Median Age | Rate (95% CI) | 5-Year Total |
Annual Average | % Malignantc | Rate (95% CI) | 5-Year Total | Annual Average | % Malignantc | Rate (95% CI) | |
| Diffuse Astrocytic and Oligodendroglial Tumors | 84,012 | 16,802 | 18.8 | 63 | 4.50 (4.47-4.53) | 48,292 | 9,658 | 100.0 | 5.48 (5.43-5.53) | 35,720 | 7,144 | 100.0 | 3.64 (3.60-3.68) |
| Diffuse astrocytoma | 7,634 | 1,527 | 1.7 | 45 | 0.46 (0.45-0.47) | 4,270 | 854 | 99.9 | 0.52 (0.51-0.54) | 3,364 | 673 | 99.9 | 0.39 (0.38-0.41) |
| Anaplastic astrocytoma | 7,046 | 1,409 | 1.6 | 52 | 0.41 (0.40-0.42) | 3,847 | 769 | 100.0 | 0.46 (0.45-0.48) | 3,199 | 640 | 100.0 | 0.36 (0.35-0.37) |
| Glioblastoma | 63,258 | 12,652 | 14.2 | 65 | 3.26 (3.24-3.29) | 36,826 | 7,365 | 100.0 | 4.08 (4.04-4.12) | 26,432 | 5,286 | 100.0 | 2.55 (2.52-2.59) |
| Oligodendroglioma | 3,687 | 737 | 0.8 | 44 | 0.23 (0.22-0.24) | 2,037 | 407 | 100.0 | 0.26 (0.25-0.27) | 1,650 | 330 | 100.0 | 0.20 (0.19-0.22) |
| Anaplastic oligodendroglioma | 1,871 | 374 | 0.4 | 49 | 0.11 (0.11-0.12) | 1,038 | 208 | 99.8 | 0.13 (0.12-0.14) | 833 | 167 | 100.0 | 0.10 (0.09-0.10) |
| Oligoastrocytic tumors | 516 | 103 | 0.1 | 45 | 0.03 (0.03-0.03) | 274 | 55 | 100.0 | 0.03 (0.03-0.04) | 242 | 48 | 100.0 | 0.03 (0.03-0.03) |
| Other Astrocytic Tumors | 6,252 | 1,250 | 1.4 | 12 | 0.42 (0.41-0.43) | 3,293 | 659 | 93.3 | 0.44 (0.43-0.46) | 2,959 | 592 | 94.5 | 0.41 (0.39-0.42) |
| Pilocytic astrocytoma | 5,339 | 1,068 | 1.2 | 11 | 0.36 (0.35-0.37) | 2,805 | 561 | 100.0 | 0.38 (0.36-0.39) | 2,534 | 507 | 100.0 | 0.35 (0.34-0.36) |
| Unique astrocytoma variants | 913 | 183 | 0.2 | 17 | 0.06 (0.06-0.06) | 488 | 98 | 55.1 | 0.06 (0.06-0.07) | 425 | 85 | 61.9 | 0.06 (0.05-0.06) |
| Non-Malignant | 381 | 76 | 0.1 | -- | 0.03 (0.02-0.03) | 219 | 44 | -- | 0.03 (0.03-0.03) | 162 | 32 | -- | 0.02 (0.02-0.03) |
| Malignant | 532 | 106 | 0.1 | -- | 0.03 (0.03-0.04) | 269 | 54 | -- | 0.03 (0.03-0.04) | 263 | 53 | -- | 0.03 (0.03-0.04) |
| Ependymal Tumors | 6,911 | 1,382 | 1.6 | 45 | 0.42 (0.41-0.43) | 3,964 | 793 | 53.6 | 0.49 (0.47-0.50) | 2,947 | 589 | 60.6 | 0.35 (0.34-0.37) |
| Non-Malignant | 3,002 | 600 | 0.7 | -- | 0.18 (0.17-0.19) | 1,840 | 368 | -- | 0.22 (0.21-0.23) | 1,162 | 232 | -- | 0.14 (0.13-0.14) |
| Malignant | 3,909 | 782 | 0.9 | -- | 0.24 (0.23-0.25) | 2,124 | 425 | -- | 0.26 (0.25-0.28) | 1,785 | 357 | -- | 0.22 (0.21-0.23) |
| Other Gliomas | 8,854 | 1,771 | 2.0 | 37 | 0.55 (0.53-0.56) | 4,476 | 895 | 99.6 | 0.57 (0.55-0.59) | 4,378 | 876 | 99.5 | 0.53 (0.51-0.55) |
| Glioma malignant, NOS | 8,753 | 1,751 | 2.0 | 37 | 0.54 (0.53-0.55) | 4,437 | 887 | 100.0 | 0.56 (0.55-0.58) | 4,316 | 863 | 100.0 | 0.52 (0.51-0.54) |
| Other neuroepithelial tumors | 101 | 20 | 0.0 | 32 | 0.01 (0.01-0.01) | 39 | 8 | 48.7 | 0.00 (0.00-0.01) | 62 | 12 | 66.1 | 0.01 (0.01-0.01) |
| Non-Malignant | 41 | 8 | 0.0 | -- | 0.00 (0.00-0.00) | 20 | 4 | -- | 0.00 (0.00-0.00) | 21 | 4 | -- | 0.00 (0.00-0.00) |
| Malignant | 60 | 12 | 0.0 | -- | 0.00 (0.00-0.00) | 19 | 4 | -- | 0.00 (0.00-0.00) | 41 | 8 | -- | 0.01 (0.00-0.01) |
| Neuronal and Mixed Neuronal-Glial Tumors | 5,339 | 1,068 | 1.2 | 26 | 0.34 (0.33-0.35) | 2,911 | 582 | 18.2 | 0.37 (0.36-0.39) | 2,428 | 486 | 17.8 | 0.31 (0.30-0.32) |
| Non-Malignant | 4,379 | 876 | -- | -- | 0.29 (0.28-0.29) | 2,382 | 476 | -- | 0.31 (0.30-0.32) | 1,997 | 399 | -- | 0.26 (0.25-0.27) |
| Malignant | 960 | 192 | -- | -- | 0.06 (0.05-0.06) | 529 | 106 | -- | 0.06 (0.06-0.07) | 431 | 86 | -- | 0.05 (0.04-0.05) |
| Choroid Plexus Tumors | 827 | 165 | 0.2 | 20 | 0.05 (0.05-0.06) | 415 | 83 | 17.6 | 0.05 (0.05-0.06) | 412 | 82 | 11.7 | 0.05 (0.05-0.06) |
| Non-Malignant | 706 | 141 | -- | -- | 0.04 (0.04-0.05) | 342 | 68 | -- | 0.04 (0.04-0.05) | 364 | 73 | -- | 0.05 (0.04-0.05) |
| Malignant | 121 | 24 | -- | -- | 0.01 (0.01-0.01) | 73 | 15 | -- | 0.01 (0.01-0.01) | 48 | 10 | -- | 0.01 (0.00-0.01) |
| Tumors of the Pineal Region | 769 | 154 | 0.2 | 34 | 0.05 (0.04-0.05) | 322 | 64 | 69.6 | 0.04 (0.04-0.05) | 447 | 89 | 53.2 | 0.06 (0.05-0.06) |
| Non-Malignant | 307 | 61 | 0.1 | -- | 0.02 (0.02-0.02) | 98 | 20 | -- | 0.01 (0.01-0.01) | 209 | 42 | -- | 0.03 (0.02-0.03) |
| Malignant | 462 | 92 | 0.1 | -- | 0.03 (0.03-0.03) | 224 | 45 | -- | 0.03 (0.02-0.03) | 238 | 48 | -- | 0.03 (0.03-0.03) |
| Embryonal Tumors | 3,170 | 634 | 0.7 | 8 | 0.22 (0.21-0.22) | 1,909 | 382 | 100.0 | 0.26 (0.25-0.27) | 1,261 | 252 | 99.8 | 0.18 (0.17-0.19) |
| Tumors of Cranial and Paraspinal Nerves | 37,048 | 7,410 | 8.3 | 58 | 2.05 (2.03-2.07) | 17,785 | 3,557 | 0.6 | 2.05 (2.02-2.08) | 19,263 | 3,853 | 0.5 | 2.06 (2.03-2.09) |
| Nerve sheath tumors | 37,015 | 7,403 | 8.3 | 58 | 2.05 (2.03-2.07) | 17,764 | 3,553 | 0.6 | 2.05 (2.02-2.08) | 19,251 | 3,850 | 0.5 | 2.06 (2.03-2.09) |
| Non-Malignant | 36,804 | 7,361 | 8.3 | -- | 2.04 (2.02-2.06) | 17,658 | 3,532 | -- | 2.04 (2.01-2.07) | 19,146 | 3,829 | -- | 2.05 (2.02-2.08) |
| Malignant | 211 | 42 | 0.0 | -- | 0.01 (0.01-0.01) | 106 | 21 | -- | 0.01(0.01-0.02 | 105 | 21 | -- | 0.01 (0.01-0.01) |
| Other tumors of cranial and paraspinal nerves | 33 | 7 | 0.0 | 55 | 0.00 (0.00-0.00) | -- | -- | -- | -- | -- | -- | -- | -- |
| Tumors of Meninges | 184,405 | 36,881 | 41.4 | 66 | 9.85 (9.81-9.90) | 51,371 | 10,274 | 2.3 | 6.00 (5.95-6.05) | 133,034 | 26,607 | 1.0 | 13.28 (13.21-13.36) |
| Meningiomas | 178,447 | 35,689 | 40.0 | 67 | 9.51 (9.46-9.55) | 48,335 | 9,667 | 1.5 | 5.64 (5.59-5.69) | 130,112 | 26,022 | 0.7 | 12.95 (12.87-13.02) |
| Non-Malignant | 176,832 | 35,366 | 39.7 | -- | 9.42 (9.38-9.47) | 47,602 | 9,520 | -- | 5.55 (5.50-5.60) | 129,230 | 25,846 | -- | 12.86 (12.79-12.93) |
| Malignant | 1,615 | 323 | 0.4 | -- | 0.09 (0.08-0.09) | 733 | 147 | -- | 0.08 (0.08-0.09) | 882 | 176 | -- | 0.09 (0.08-0.09) |
| Mesenchymal tumors | 5,815 | 1,163 | 1.3 | 51 | 0.34 (0.33-0.35) | 2,953 | 591 | 13.6 | 0.35 (0.34-0.37) | 2,862 | 572 | 12.7 | 0.33 (0.32-0.34) |
| Non-Malignant | 5,049 | 1,010 | 1.1 | -- | 0.30 (0.29-0.30) | 2,551 | 510 | -- | 0.30 (0.29-0.32) | 2,498 | 500 | -- | 0.29 (0.28-0.30) |
| Malignant | 766 | 153 | 0.2 | -- | 0.04 (0.04-0.05) | 402 | 80 | -- | 0.05 (0.04-0.05) | 364 | 73 | -- | 0.04 (0.04-0.05) |
| Primary melanocytic lesions | 143 | 29 | 0.0 | 61 | 0.01 (0.01-0.01) | 83 | 17 | 69.9 | 0.01 (0.01-0.01) | 60 | 12 | 51.7 | 0.01 (0.00-0.01) |
| Non-Malignant | 54 | 11 | 0.0 | -- | 0.00 (0.00-0.00) | 25 | 5 | -- | 0.00 (0.00-0.00) | 29 | 6 | -- | 0.00 (0.00-0.00) |
| Malignant | 89 | 18 | 0.0 | -- | 0.00 (0.00-0.01) | 58 | 12 | -- | 0.01 (0.01-0.01) | 31 | 6 | -- | 0.00 (0.00-0.00) |
| Lymphomas and Hematopoietic Neoplasms | 8,525 | 1,705 | 1.9 | 67 | 0.45 (0.44-0.46) | 4,352 | 870 | 99.9 | 0.49 (0.48-0.51) | 4,173 | 835 | 99.8 | 0.41 (0.39-0.42) |
| Lymphoma | 8,482 | 1,696 | 1.9 | 67 | 0.45 (0.44-0.46) | 4,328 | 866 | 99.9 | 0.49 (0.48-0.51) | 4,154 | 831 | 99.8 | 0.41 (0.39-0.42) |
| Other hematopoietic neoplasms | 43 | 9 | 0.0 | 59 | 0.00 (0.00-0.00) | 24 | 5 | 95.8 | 0.00 (0.00-0.00) | 19 | 4 | 94.7 | 0.00 (0.00-0.00) |
| Germ Cell Tumors | 1,280 | 256 | 0.3 | 15 | 0.09 (0.08-0.09) | 942 | 188 | 89.4 | 0.12 (0.12-0.13) | 338 | 68 | 79.3 | 0.05 (0.04-0.05) |
| Non-Malignant | 170 | 34 | 0.0 | -- | 0.01 (0.01-0.01) | 100 | 20 | -- | 0.01 (0.01-0.02) | 70 | 14 | -- | 0.01 (0.01-0.01) |
| Malignant | 1,110 | 222 | 0.2 | -- | 0.07 (0.07-0.08) | 842 | 168 | -- | 0.11 (0.10-0.12) | 268 | 54 | -- | 0.04 (0.03-0.04) |
| Tumors of Sellar Region | 79,996 | 15,999 | 17.9 | 51 | 4.69 (4.65-4.72) | 35,594 | 7,119 | 0.2 | 4.18 (4.14-4.23) | 44,402 | 8,880 | 0.1 | 5.28 (5.23-5.33) |
| Tumors of the pituitary | 76,863 | 15,373 | 17.2 | 51 | 4.50 (4.47-4.53) | 33,981 | 6,796 | 0.2 | 3.98 (3.94-4.03) | 42,882 | 8,576 | 0.1 | 5.10 (5.05-5.15) |
| Non-Malignant | 76,755 | 15,351 | 17.2 | -- | 4.49 (4.46-4.52) | 33,913 | 6,783 | -- | 3.98 (3.93-4.02) | 42,842 | 8,568 | -- | 5.09 (5.04-5.14) |
| Malignant | 108 | 22 | 0.0 | -- | 0.01 (0.00-0.01) | 68 | 14 | -- | 0.01 (0.01-0.01) | 40 | 8 | -- | 0.00 (0.00-0.01) |
| Craniopharyngioma | 3,133 | 627 | 0.7 | 45 | 0.19 (0.18-0.20) | 1,613 | 323 | 0.4 | 0.20 (0.19-0.21) | 1,520 | 304 | 0.1 | 0.18 (0.17-0.19) |
| Unclassified Tumors | 18,404 | 3,681 | 4.1 | 65 | 1.03 (1.02-1.05) | 8,542 | 1,708 | 38.5 | 1.05 (1.02-1.07) | 9,862 | 1,972 | 35.1 | 1.02 (1.00-1.04) |
| Hemangioma | 4,215 | 843 | 0.9 | 50 | 0.25 (0.24-0.26) | 1,956 | 391 | 0.0 | 0.24 (0.23-0.25) | 2,259 | 452 | 0.0 | 0.26 (0.25-0.27) |
| Neoplasm, unspecified | 13,647 | 2,729 | 3.1 | 70 | 0.75 (0.73-0.76) | 6,292 | 1,258 | 51.8 | 0.77 (0.75-0.79) | 7,355 | 1,471 | 46.7 | 0.73 (0.71-0.75) |
| Non-Malignant | 6,954 | 1,391 | 1.6 | -- | 0.39 (0.38-0.40) | 3,032 | 606 | -- | 0.37 (0.36-0.39) | 3,922 | 784 | -- | 0.41 (0.40-0.42) |
| Malignant | 6,693 | 1,339 | 1.5 | -- | 0.36 (0.35-0.36) | 3,260 | 652 | -- | 0.40 (0.38-0.41) | 3,433 | 687 | -- | 0.32 (0.31-0.33) |
| All other | 542 | 108 | 0.1 | 37.5 | 0.03 (0.03-0.04) | 294 | 59 | 9.2 | 0.04 (0.03-0.04) | 248 | 50 | 12.9 | 0.03 (0.03-0.03) |
| Non-Malignant | 483 | 97 | 0.1 | -- | 0.03 (0.03-0.04) | 267 | 53 | -- | 0.03 (0.03-0.04) | 216 | 43 | -- | 0.03 (0.02-0.03) |
| Malignant | 59 | 12 | 0.0 | -- | 0.00 (0.00-0.01) | 27 | 5 | -- | 0.00 (0.00-0.01) | 32 | 6 | -- | 0.00 (0.00-0.01) |
| TOTAL d | 445,792 | 89,158 | 100.0 | 61 | 24.71 (24.63-24.78) | 184,168 | 36,834 | 38.3 | 21.60 (21.50-21.70) | 261,624 | 52,325 | 21.4 | 27.62 (27.51-27.73) |
| Non-Malignant | 319,447 | 63,889 | 71.7 | -- | 17.69 (17.62-17.75) | 113,709 | 22,742 | -- | 13.36 (13.28-13.44) | 205,738 | 41,148 | -- | 21.68 (21.58-21.78) |
| Malignant | 126,345 | 25,269 | 28.3 | -- | 7.02 (6.98-7.06) | 70,459 | 14,092 | -- | 8.24 (8.18-8.30) | 55,886 | 11,177 | -- | 5.94 (5.89-5.99) |
aAnnual average cases are calculated by dividing the five-year total by five.
bRates are per 100,000 and are age-adjusted to the 2000 US standard population.
cAssigned behavior code of /3 (see Table 2).
dRefers to all brain tumors including histopathologies not presented in this table.
-- Counts and rates are not presented when fewer than 16 cases were reported for the specific category. The suppressed cases are included in the counts and rates for totals.
Abbreviations: CBTRUS, Central Brain Tumor Registry of the United States; NPCR, National Program of Cancer Registries; SEER, Surveillance, Epidemiology, and End Results Program; CI, confidence interval; NOS, not otherwise specified.