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. 2022 Oct 5;24(Suppl 5):v1–v95. doi: 10.1093/neuonc/noac202

Table 6.

Five-Year Total, Annual Average Totala, and Average Annual Age-Adjusted Incidence Ratesb with 95% Confidence Intervals for Selected Non-Malignant Histopathologies by Sex, Age Group at Diagnosis, Race, Hispanic Ethnicity, and Histopathology, CBTRUS Statistical Report: US Cancer Statistics – NPCR and SEER, 2015-2019

Group Vestibular Schwannomac Pituitary Adenomad WHO Grade I Meningiomae WHO Grade II Meningiomaf
5-Year Total Annual Average Rate (95% CI) 5-Year Total Annual Average Rate (95% CI) 5-Year Total Annual Average Rate (95% CI) 5-Year Total Annual Average Rate (95% CI)
Sex
Male 13,078 2,616 1.49 (1.47-1.52) 29,868 5,974 3.49 (3.45-3.53) 16,042 3,208 1.84 (1.81-1.87) 4,050 810 0.46 (0.45-0.48)
Female 14,795 2,959 1.56 (1.53-1.58) 37,282 7,456 4.41 (4.36-4.45) 43,389 8,678 4.47 (4.43-4.51) 5,653 1,131 0.60 (0.58-0.61)
Age Groups
0-14 years 213 43 0.07 (0.06-0.08) 937 187 0.31 (0.29-0.33) 108 22 0.04 (0.03-0.04) 78 16 0.03 (0.02-0.03)
15-39 years 3,687 737 0.70 (0.68-0.72) 19,150 3,830 3.56 (3.51-3.61) 4,552 910 0.89 (0.87-0.92) 1,063 213 0.20 (0.19-0.22)
40-64 years 14,399 2,880 2.59 (2.54-2.63) 28,324 5,665 5.40 (5.34-5.47) 27,964 5,593 5.03 (4.97-5.09) 4,578 916 0.83 (0.80-0.85)
65+ years 9,574 1,915 3.74 (3.66-3.82) 18,739 3,748 7.45 (7.34-7.56) 26,807 5,361 10.73 (10.60-10.86) 3,984 797 1.59 (1.54-1.64)
Race
White 23,866 4,773 1.62 (1.59-1.64) 47,724 9,545 3.51 (3.48-3.55) 47,661 9,532 3.15 (3.12-3.18) 7,354 1,471 0.49 (0.48-0.51)
Black 1,546 309 0.70 (0.67-0.74) 13,520 2,704 6.24 (6.13-6.35) 7,662 1,532 3.61 (3.53-3.69) 1,547 309 0.71 (0.68-0.75)
American Indian/Alaska Native 161 32 0.76 (0.64-0.89) 614 123 2.90 (2.66-3.15) 409 82 2.13 (1.92-2.35) 57 11 0.30 (0.22-0.39)
Asian or Pacific Islander 1,347 269 1.25 (1.18-1.32) 2,883 577 2.71 (2.61-2.81) 2,325 465 2.23 (2.13-2.32) 507 101 0.49 (0.44-0.53)
Hispanic Ethnicity
Non-Hispanic 25,447 5,089 1.61 (1.59-1.63) 55,782 11,156 3.82 (3.78-3.85) 53,374 10,675 3.28 (3.25-3.31) 8,731 1,746 0.55 (0.54-0.56)
Hispanic 2,426 485 1.03 (0.99-1.07) 11,368 2,274 4.51 (4.42-4.59) 6,057 1,211 2.77 (2.69-2.84) 972 194 0.43 (0.41-0.46)
TOTAL 27,873 5,575 1.52 (1.50-1.54) 67,150 13,430 3.91 (3.88-3.94) 59,431 11,886 3.21 (3.18-3.24) 9,703 1,941 0.53 (0.52-0.54)

aAnnual average cases are calculated by dividing the five-year total by five.

bRates are per 100,000 and are age-adjusted to the 2000 US standard population.

cICD-O-3 histopathology code 9560/0 and ICD-O-3 topography code C72.4 and C72.5.

dICD-O-3 histopathology code 8272/0 and ICD-O-3 topography code C75.1.

eICD-O-3 histopathology codes 9530/0, 9531/0, 9532/0, 9533/0, 9534/0, and 9537/0. WHO grade may be reported according to 2007 or 2016 WHO classification depending on year of diagnosis, in which roman numerals are used to denote tumor grade.

fICD-O-3 histopathology codes 9530/1, 9531/1, 9532/1, 9533/1, 9534/1, 9537/1, 9538/1, and 9539/1. WHO grade may be reported according to 2007 or 2016 WHO classification depending on year of diagnosis, in which roman numerals are used to denote tumor grade.

- Counts and rates are not presented when fewer than 16 cases were reported for the specific category. The suppressed cases are included in the counts and rates for totals.

Abbreviations: CBTRUS, Central Brain Tumor Registry of the United States; US, United States; NPCR, National Program of Cancer Registries; SEER, Surveillance, Epidemiology, and End Results Program; WHO, World Health Organization; CI, confidence interval.