Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Models depicting possible roles for ABC transporters in promoting AML through transport of endogenous ligands. MRP4 effluxes PGE2, which acts on EP receptors to increase LSC and metastasis. MRP4 also modulates cAMP levels. LTC4 effluxed by MRP1 can act on CysLTR to promote LSC survival and proliferation. Heme biosynthesis is upregulated in highly proliferating cells. ABCG2 might alleviate toxic effect of excess PPIX when heme production is inadequate.
