Fig. 1.

Trial design of the randomized, double-masked, vehicle-controlled, multicentre, phase IIb ONSET-1 and phase III ONSET-2 trials in adults with dry eye disease [25, 26], with further information available in Table 1. Efficacy results for the intranasal varenicline solution dosage approved in the USA are reported in the animated figure (available online). BID twice daily, BL baseline, DED dry eye disease, LSM least squares mean, NA not reported, OR odds ratio, pts patients, STS Schirmer test score