Table 2.

Representative selection of marker genes for mouse organ-specific vascular subtypes

Organ system	Developmental stage	Vascular EC subtype	Marker genes	Refs.
Multi-organ	Embryonic or adult	Pan-endothelial	Pecam1, Kdr, Cldn5, Emcn, Cdh5, Tie1, Egfl7	2,80,85,131
		Vein	Apj, Nr2f2, Vwf	29,65,66
		Artery	Gja4, Mecom	29,66
Heart	Embryonic	Artery	Gja4, Gja5	66
		Pre-artery or arteriole	Gja4, Gja5, Unc5b, Hey1, Slc45a4	29,66
		Vein	Nr2f2, Apj, Nr2f2	29,66
		Capillary	Aplnr, Car4	66
	Adult	Tissue-specific EC	Wt1, Slc28a2, Eepd1, Kcna5, Car8, Fbln1, Meox2, Rftn1, Lamb1, Myadm	2
		Artery	Apln, Dll4, Notch1, Mecom, Igfbp3, Cxcr4, Cx40	29
Lung	Adult	Artery	Mgp, Cdh13, Htra1, Bmx, Fbln2, Sulf1	131
		Vein	Slc6a2, Bst1, Car8, Amigo2, Mutn1, Csrp2	131
		Tissue-specific EC	Grtp1, Adrb1, Scn7a, Tmem100, Hpgd, Foxf1a, Nckap5, Rasgef1a, Fendrr, Prx	2
		Capillary (aCap)	Car4, Ednrb, Fibin, Tbx2, Rprml, Chst1, Apln	81,131
		Capillary (gCap)	Aplnr, Gpihbp1, Plvap, Cd93, Ptprb, Cemip2, Tek, Cxcl12	81,131
Brain	Embryonic	Tissue-specific EC	Foxf2, Foxl2, Foxq1, Lef1, Ppard, Zfp551, Zic3	84
	Adult	Tissue-specific EC	Slco1c1, Slco1a4, Slc22a8, Mfsd2a, Slc38a3, Spock2, Foxf2, Edn3, Stra6, Slc38ak	2
		Artery	Gkn3, Sema3g, Efnb2	65
		Venule	Slc38a5	65
		Capillary or vein	Slc16a1	65
Kidney	Adult	Tissue-specific EC	Egfl7, Dram1, Dkk2, Esm1, Igfbp5, Pbx1, Boc, Igfbp3, Irx3, Tnfaip2, Ptpru	87,88
		Glomerular EC	Pi16, Plat, Ehd3, Cyb4b1, Tspan7, Lpl	143
		Cortical EC	Igfbp3, Plvap, Npr3	143
		Medullary EC	Igf1, Cryab, Igfbp7, Cd36, Aqp1, Ifi27l2a	143
Liver	Embryonic or adult	Portal vein	Ly6a, Cd34, Cd9, Ephb2, Gja5, Sox17	97
		LSEC	Mrc1, Fcgr2b, Stab1, Stab2	97
	Adult	Tissue-specific EC	c-Maf, Clec4g, Fcgr2b, Stab2, Oit3, Bmp2, Aass, Mrc1, Plxnc1, Wnt2	2,136
		LSEC zone 1	Dll4, Efnb2, Ltbp4, Msr1, Ntn4	98,99
		LSEC zone 2 or 3	Rspo3, Wnt2, Wnt9b	98,99

aCap, aerocyte capillary; EC, endothelial cell; gCap, general capillary; LSEC, liver sinusoidal endothelial cell.