Fig. 2. Detected variants of N protein: the relative positions of amino-acid substitutions (with respect to the Wuhan reference sequence – WIV04) found in the N gene of 17 full-length sequences of SARS-CoV-2 are shown.

The sequences are from individuals showing either discordant, antigen –/ molecular + or concordant antigen +/ molecular +, at molecular and antigenic swab tests. Regions of mapped B-cell epitopes are highlighted on the Wuhan reference (hatched boxes) and on the sequences of the N gene (grey-shaded boxes). Only sequences around amino-acid substitutions (boxed on the Wuhan reference WIV04) are shown. Mutations found in molecular +/ antigen +, and molecular +/ antigen – sequences are shaded in yellow and highlighted in red. The last six sequences do not contain any mutation in the N gene according to the Wuhan reference sequence.