Table 1.
Size and characteristics of the large-scale CRC metagenomic datasets included in this study.
| Dataset | Groups (N) | Age (mean +/− s.d.) | BMI (mean +/− s.d.) | Sex F(%)/M(%) | Country | # of reads (x 10^9) |
|---|---|---|---|---|---|---|
| ZellerG_2014 (Zeller et al. 2014) | Control (61) Adenoma (42) CRC (53) |
60.6 +/− 11.4 63 +/− 9.1 66.8 +/− 10.9 |
24.7 +/− 3.2 25.9 +/− 4.1 25.5 +/− 5.2 |
54.1/45.9 28.5/71.5 45.2/54.8 |
France | 9.4 |
| YuJ_2015 (Yu et al. 2015) | Control (54) CRC (74) |
61.8 +/− 5.7 66 +/− 10.6 |
23.5 +/− 3 24 +/− 3.2 |
38.9/61.1 35.1/64.9 |
China | 7.2 |
| FengQ_2015 (Feng et al. 2015) | Control (61)* Adenoma (47) CRC (46) |
67 +/− 6.5 66.5 +/− 7.9 67 +/− 10.9 |
27.6 +/− 3.8 28 +/− 4.7 26.5 +/− 3.5 |
41/59 51.1/48.9 39.1/60.9 |
Austria | 8.3 |
| VogtmannE_2016 (Vogtmann et al. 2016) | Control (52) CRC (52) |
61.2 +/− 11 61.8 +/− 13.6 |
25.3 +/− 4.2 24.9 +/− 4.2 |
28.8/71.2 28.8/71.2 |
USA | 6.9 |
| HanniganGD_2018 (Hannigan et al. 2018) | Control (28) Adenoma (27) CRC (27) |
NA | NA | NA | USA (54) Canada (28) |
0.5 |
| Cohort1 (This study) | Control (24) Adenoma (27) CRC (29) |
67.9 +/− 7.1 62.8 +/− 8.6 71.4 +/− 8.2 |
25.3 +/− 3.5 25.3 +/− 4.1 25.7 +/− 4.1 |
45.8/54.1 40.7/59.3 20.7/79.3 |
Italy | 8.2 |
| Cohort2 (This study) | Control (28) CRC (32) |
57.8 +/− 8.3 58.4 +/− 8.4 |
24.6 +/− 3.8 26.8 +/− 4.3 |
42.9/57.1 28.1/71.9 |
Italy | 5.1 |
| Total |
Control (308)
Adenoma (143) CRC (313) |
-- | -- | -- | -- | 45.6 |
*
Numbers differed from the original sample numbers (N = 61 instead of 63) reported in the article due to metadata and/or sequence processing issues. NA = Not available.