Table 3.
Venetoclax and navitoclax pharmacokinetic parameters at steady state (day 8)
| Parametera | Venetoclax | Navitoclax | ||||
|---|---|---|---|---|---|---|
| Navitoclax dose level | 25 mg | 50 mg | 100 mg | 25 mg | 50 mg | 100 mg |
| n | 15 | 11 | 14 | 15 | 10 | 16 |
| Tmax, hours | 8 (4–8) | 6 (4–8) | 6 (4–6) | 8 (4–8) | 4 (0–8) | 6 (4–8) |
| Cmax, μg/mL | 1.21 (76%) | 1.63 (58%) | 1.04 (57%) | 0.330 (63%) | 0.969 (38%) | 1.57 (55%) |
| AUC0–8, μg × h/mL | 6.64 (81%) | 8.14 (44%) n = 10 | 5.79 (63%) | 1.71 (56%) | 5.01 (39%) n = 9 | 8.99 (59%) |
| AUC0–24, μg × h/mL | 18.7 (74%) | 23.7 (45%) n = 7 | 11.8 (90%) n = 3 | 5.19 (59%) | 13.5 (47%) n = 7 | 9.58 (54%) n = 3 |
a
Parameters presented as geometric mean (% coefficient of variation) except for Tmax, which is presented as median (range).
Abbreviations: AUC0–8, area under the plasma concentration-time curve from day 0–8; AUC0–24, area under the plasma concentration-time curve from day 0–24; Cmax, maximum observed plasma concentration; Tmax, peak time to Cmax.