Table 3.
RRs with 95% CI for MLR and other factors predicting CVD events after initiation of dialysis therapy
| Parameter | CVD events excluding sudden death |
All CVD events |
|||
|---|---|---|---|---|---|
| RRs (95% CI) | p value | RRs (95% CI) | p value | ||
| Unadjusted | |||||
| Binary analysis; MLR, >median† | 2.21 (1.13–4.35) | 0.021* | 2.02 (1.09–3.76) | 0.026* | |
| Analysis as continuous variable; MLR (per unit)†† | 6.03 (1.30–23.66) | 0.015* | 4.54 (1.03–17.08) | 0.034* | |
| Analysis as continuous variable; MLR (whole)††† | 7.10 (1.32–31.57) | 0.015* | 5.22 (1.03–21.12) | 0.015* | |
| Model 1 | |||||
| MLR, >median† | 2.44 (1.22–4.85) | 0.011* | 2.21 (1.17–4.14) | 0.014* | |
| Age, >61 years | 2.21 (1.12–4.35) | 0.022* | 1.82 (0.98–3.38) | 0.057 | |
| Gender, man | 2.55 (1.11–5.91) | 0.029* | 2.70 (1.23–5.90) | 0.013* | |
| Diabetes mellitus, presence | 5.83 (2.61–13.0) | <0.0001* | 4.58 (2.26–9.26) | <0.0001* | |
| Model 2 | |||||
| MLR (per unit)†† | 6.04 (1.18–26.41) | 0.022* | 4.35 (0.91–17.88) | 0.051 | |
| MLR (per whole)††† | 7.12 (1.20–35.60) | 0.022* | 4.98 (0.90–35.60) | 0.051 | |
| Age, >61 years | 2.10 (1.06–4.15) | 0.032* | 1.77 (0.96–3.30) | 0.069 | |
| Gender, man | 2.33 (0.99–5.48) | 0.052 | 2.51 (1.13–5.56) | 0.023* | |
| Diabetes mellitus, presence | 5.62 (2.52–12.51) | <0.0001* | 4.42 (2.19–8.91) | <0.0001* | |
| Model 3 (model 2 + smoking habit + CRP) | |||||
| MLR, >median† | 2.37 (1.19–4.72) | 0.014* | 2.10 (1.12–3.96) | 0.022* | |
| MLR (per unit)†† | 5.56 (1.05–25.71) | 0.028* | 3.93 (0.86–17.99) | 0.078 | |
| MLR (per whole)††† | 6.56 (1.12–34.57) | 0.028* | 4.45 (0.85–23.41) | 0.078 | |
RRs, relative risks; MLR, monocyte/lymphocyte ratio; CVD, cardiovascular disease; CI, confidence interval.
†
RR was calculated by dividing the MLR into 2 groups' ratio as an ordinal variable.
††
By MLR as a continuous variable when changing by 1 unit.
†††
By MLR as a continuous variable when changing by whole range.
*
p < 0.05.