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. Author manuscript; available in PMC: 2022 Oct 5.
Published in final edited form as: Cell Rep. 2022 Sep 13;40(11):111362. doi: 10.1016/j.celrep.2022.111362

Figure 2. Single cell-RNA sequencing reveals adipocyte mesenchymal transition during mammary tumor progression.

Figure 2.

EGFP-labeled de-differentiated adipocytes from PyMTChaser and AlloChaser mice were isolated by FACS and subjected to scRNA-seq.

(A and B) T-distributed stochastic neighbor embedding (t-SNE) plots. Clustering of PyMT-EGFP + or allograft (Allo)-EGFP + cells, with mean number of genes per cell equals 1, 163 or 2, 173, respectively.

(C) Representative adipocyte early differentiation marker genes.

(D) Representative mesenchymal stem cell/adipocyte precursor marker genes. The y axis is the log-scale normalized read count.