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. 2022 Oct 5;21:192. doi: 10.1186/s12943-022-01659-w

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — circPVT1 is highly expressed in NPC and associated with poor prognosis. A. Schematic representation of the circPVT1 stucture. circPVT1 is 410 nt in length and circularly spliced from exon 2 of the PVT1 gene (RefSeq: NC_000008.11) on chromosome 8q24.21. B. circPVT1 was more stable than the liner PVT1 in NPC cells after RNase R treatment. ***, p < 0.001. C. Intracellular localization of circPVT1 was examined using fluorescence in situ hybridization. Scale bar, 20 μm. D. Expression of circPVT1 was examined in NPC (n = 60) and non-tumor nasopharyngeal epithelial tissues (NPE) (n = 26) by qRT-PCR. Data were represented as mean ± standard deviation (SD). ***, p < 0.001. E. The expression of circPVT1 in correlation with the clinical stages in 26 NPE and 60 NPC samples. **, p < 0.01; ***, p < 0.001. F. Expression of circPVT1 was examined in NPC (n = 159) and non-tumor nasopharyngeal epithelial tissues (NPE) (n = 29) by in situ hybridization; Scale bar: 100 × , 100 μm; 400 × , 20 μm. Left: Representative images of the circPVT1 expression in NPC and NPE tissues. Right: The statistical results of the circPVT1 expression in NPC and NPE tissues. ***, p < 0.001. G. Overall survival (OS) analysis of patients with low and high circPVT1 staining using a Kaplan–Meier curve. H-I. The circPVT1 staining in correlation with the clinical stages (H) and N stages (I) of patients with NPC. *, p < 0.05. I. High circPVT1 expression was associated with distant metastasis in NPC patients. *, p < 0.05