Table 4.
Stress response defense virulence in B. cereus s.s. 3A ES
| Subclass | Subsystem Name | Gene Count | Role Count | Active |
|---|---|---|---|---|
| Toxins and superantigens | Pore-forming cytolytic toxins | 1 | 1 | active |
| Stress Response: Osmotic stress | Choline uptake and conversion to betaine clusters | 8 | 5 | active |
| Stress Response: Osmotic stress | Osmoregulation | 2 | 2 | active |
| Stress Response: Heat/cold shock | Heat shock dnaK gene cluster extended | 16 | 16 | active |
| Stress Response: Heat/cold shock | Cold shock proteins of CSP family | 6 | 2 | active |
| Stress Response: Electrophile toxicity | Bacillithiol synthesis | 4 | 3 | active |
| Stress Response | Cluster containing Glutathione synthetase | 2 | 2 | likely |
| Stress Response | Glutathione: Non-redox reactions | 4 | 2 | likely |
| Stress Response | CoA disulfide thiol-disulfide redox system | 1 | 2 | active |
| Stress Response | Protection from Reactive Oxygen Species | 9 | 7 | active |
| Stress Response | Universal stress protein family | 2 | 1 | active |
| Stress Response | Repair of Iron Centers | 1 | 1 | active |
| Stress Response | Glutathione: Redox cycle | 1 | 1 | active |
| Stress Response | Stress proteins YciF, YciE | 1 | 1 | active |
| Resistance to antibiotics and toxic compounds | Aminoglycoside modifying enzymes: O-nucleotidyltransferases | 1 | 1 | active |
| Resistance to antibiotics and toxic compounds | Fosfomycin resistance | 1 | 1 | active |
| Resistance to antibiotics and toxic compounds | Resistance to Daptomycin | 14 | 7 | active |
| Resistance to antibiotics and toxic compounds | Resistance to Vancomycin and Teicoplanin | 7 | 3 | likely |
| Resistance to antibiotics and toxic compounds | Beta-lactamases Ambler class A | 2 | 1 | active |
| Resistance to antibiotics and toxic compounds | Antibiotic targets in protein synthesis | 9 | 8 | active |
| Resistance to antibiotics and toxic compounds | Antibiotic targets in metabolic pathways | 7 | 5 | active |
| Resistance to antibiotics and toxic compounds | Antibiotic targets in DNA processing | 4 | 4 | active |
| Resistance to antibiotics and toxic compounds | VraTSR and LiaFSR three-component regulatory systems | 5 | 5 | active |
| Resistance to antibiotics and toxic compounds | Copper homeostasis: copper tolerance | 1 | 1 | active |
| Resistance to antibiotics and toxic compounds | Fusidic acid resistance | 2 | 2 | likely |
| Resistance to antibiotics and toxic compounds | Macrolides, lincosamides, streptogramins, ketolides, oxazolidinones (MLSKO) resistance: enzymatic degradation | 1 | 1 | active |
| Resistance to antibiotics and toxic compounds | Bacitracin resistance | 3 | 3 | active |
| Resistance to antibiotics and toxic compounds | Antibiotic targets in cell wall biosynthesis | 6 | 3 | active |
| Resistance to antibiotics and toxic compounds | Vancomycin resistance, D-Ala-D-Ala dipeptidases and carboxypeptidases | 1 | 1 | active |
| Resistance to antibiotics and toxic compounds | Arsenic resistance | 7 | 5 | active |
| Resistance to antibiotics and toxic compounds | Antibiotic targets in transcription | 3 | 3 | active |
| Resistance to antibiotics and toxic compounds | Aminoglycoside modifying enzymes: N-acetyltransferases | 1 | 1 | likely |
| Resistance to antibiotics and toxic compounds | Beta-lactamases Ambler class B | 1 | 1 | active |
| Resistance to antibiotics and toxic compounds | Resistance to Triclosan | 1 | 1 | active |
| Resistance to antibiotics and toxic compounds | Resistance to chromium compounds | 1 | 1 | active |
| Resistance to antibiotics and toxic compounds | Mupirocin resistance | 2 | 1 | likely |
| Resistance to antibiotics and toxic compounds | Chloramphenicol resistance | 1 | 1 | active |
| Resistance to antibiotics and toxic compounds | Tetracycline resistance, all mechanisms | 2 | 2 | active |
| Resistance to antibiotics and toxic compounds | Macrolides, lincosamides, streptogramins, ketolides, oxazolidinones (MLSKO) resistance: ribosomal protection | 1 | 1 | active |
| Invasion and intracellular resistance | Listeria surface proteins: Internalin-like proteins | 3 | 1 | active |
| Host–pathogen interactions | Hydrolysis of sphingomyelin | 2 | 2 | active |
| Hfl operon | 5 | 5 | active |