Fig. 4.
The resident CNS IL-10 immune niche in WT and SLAMF7−/− mice during EAE. A Frequency of resident (IV−) versus circulating (IV+) CNS immune cells in WT-IL-10GFP (n = 3) and SLAMF7−/−-IL-10GFP (n = 5) mice during EAE induced with rmMOG1–125. B Frequency of IL-10 producing cells in the CNS of WT-IL-10GFP (n = 3) and SLAMF7−/−-IL-10GFP (n = 5) mice during EAE induced with rmMOG1–125. C UMAP of all CNS-resident IL-10+ immune cells in WT-IL-10GFP and SLAMF7−/−-IL-10GFP mice during EAE. D Pie charts of all CNS-resident IL-10+ immune cells in WT-IL-10GFP and SLAMF7−/−-IL-10GFP mice during EAE. Groups in D compared with a GLMM. Data in A–D representative of a single experiment. BAMS, border-associated macrophages; MdCs, myeloid-derived cells