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. 2022 Oct 4;20:450. doi: 10.1186/s12967-022-03665-4

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — HNRNPR overexpression in ESCA and pan-cancer. A HNRNPR mRNA was expressed in various pan-cancers. B The expression level of HNRNPR mRNA was evaluated by analyzing TCGA data in various pan-cancers. C, D The difference in HNRNPR expression between ESCA cancer tissue and normal tissue in the TCGA and GSE45670 datasets. E The difference in HNRNPR expression between ESCA cancer and para-cancerous tissues in the GSE20347 dataset. G, F The HNRNPR expression and score in cancer and para-cancerous tissues of patients with ESCA were detected by IHC. H The difference in HNRNPR mRNA expression between cancer and para-cancerous tissues of ESCA patients based on qPCR test. *P < 0.05, **P < 0.01, ***P < 0.001