Table 1.

Functional characterization of PVT1 in respiratory system tumors

Tumor type	Expression	Role	Function role	miRNAs	Related genes	References
Nasopharyngeal carcinoma	Upregulation	Oncogene	Proliferation	miR-1207	PI3K/AKT	[54]
Nasopharyngeal carcinoma	Upregulation	Oncogene	Proliferation and radioresistance	miR-515-5p	PIK3CA	[55]
Lung cancer	Upregulation	Oncogene	Proliferation	/	P15/P21	[6]
Lung cancer	Upregulation	Oncogene	Invasion and proliferation	miR-497	/	[56]
Lung cancer	Upregulation	Oncogene	Proliferation	/	LATS2	[42]
Lung cancer	Upregulation	Oncogene	Proliferation, migration, invasion, and EMT	miR-497	YAP1	[57]
Lung cancer	Upregulation	Oncogene	Proliferation and migration	miR-526b	EZH2	[58]
Lung cancer	Upregulation	Oncogene	Invasion	miR-200a/200b	MMP9	[59]
Lung cancer	Upregulation	Oncogene	Proliferation	miR-199a-5p	HIF-1α	[60]
Lung cancer	Upregulation	Oncogene	Angiogenesis	miR-29c	VEGF	[61]
Lung cancer	Upregulation	Oncogene	Proliferation and metastasis	miR-128	VEGFC	[62]
Lung cancer	Upregulation	Oncogene	Proliferation, migration, and invasion	miR-361-3p	SOX9	[63]
Lung cancer	Upregulation	Oncogene	Migration and invasion	miR-760	IL-6	[64]
Lung cancer	Upregulation	Oncogene	Proliferation	miR-17-5p	BAMBI	[65]
Lung cancer	Upregulation	Oncogene	Proliferation and migration	miR-148	RAB34	[66]
Lung cancer	Upregulation	Oncogene	Proliferation, migration, and invasion	miR-551b	FGFR1	[67]
Lung cancer	Upregulation	Oncogene	Invasion and growth	miR-378c	SLC2A1	[68]
Lung cancer	Upregulation	Oncogene	Radioresistance	miR-195	/	[69]
Lung cancer	Upregulation	Oncogene	Radioresistance	miR-424-5p	CARM1	[70]
Lung cancer	Upregulation	Oncogene	Cisplatin-resistance	miR-181a-5p	SP1	[71]
Lung cancer	Upregulation	Oncogene	Cisplatin-resistance	miR-216b	Beclin-1	[72]