Table 2.
Included studies
| Author/trial ID | Country/region | Description of population | Tests assessed |
|---|---|---|---|
| Abubakar et al. [17] | UK | Migrants, Contacts |
1. QFT with 4R 2. QFT with 6H 3. QFT with 3HP 4. TST with 4R 5. TST with 6H 6. TST with 3HP 7. CXR |
| Al Abri et al. [20] | Oman | Migrants |
TST QFT-GIT T-SPOT.TB CXR |
| Auguste et al. [16] | UK | Migrants, Immunocompromised, Children |
TST/INH TST/RIF IGRA/INH IGRA/RIF SEQ/INH SEQ/RIF (SEQ = BC + TST at time of medical examination) No intervention |
| Campbell et al. [13] | Canada | Migrants |
Base case (no screening or treatment for LTBI) IGRA/INH TST/INH |
| Campbell et al. [14] | Canada | Migrants |
Base case (BC): CXR + medical history + symptom screen BC + TST/INH BC + TST/RIF BC + IGRA/INH BC + IGRA/RIF SEQ/INH (SEQ = BC + TST at time of medical examination) SEQ/RIF |
| Campbell et al.a [15] | Canada (British Columbia) | Migrants | QFT, TST |
| Capocci et al. [22] | UK | HIV+ |
NICE Guideline (not in abstract but taken from guideline) IGRA + TST only if CD4 < 500 BHIVA Guideline (not in abstract but taken from guideline) IGRA test only if from sSA: ART < 2 years from MI: CD4 < 400 and ART < 2 years from low TB incidence country:CD4 < 350 and ART < 6 months |
| Capocci et al. [23] | UK | HIV+ |
NICE Guideline (not in abstract but taken from guideline) IGRA + TST only if CD4 < 500 BHIVA Guideline (not in abstract but taken from guideline) IGRA test only if from sSA: ART < 2 years from MI: CD4 < 400 and ART < 2 years from low TB incidence country:CD4 < 350 and ART < 6 months |
| Capocci et al. [24] | UK | HIV+ |
Testing all patients IGRA for all NICE Guideline IGRA + TST only if CD4 < 500 BHIVA Guideline IGRA test only if from sSA: ART < 2 years from MI: CD4 < 400 and ART < 2 years from low TB incidence country:CD4 < 350 and ART < 6 months |
| Capocci et al. [25] | UK | HIV+ | TST, IGRA |
| Capocci et al. [26] | UK | HIV+ | TST, IGRA, CXR |
| Capocci et al. [27] | UK | HIV+ | TST, IGRA, CXR |
| Eralp et al. [35] | UK | Healthcare workers |
TST IGRA TST + IGRA (X-ray used to confirm +ve test result) |
| Goodell et al. [12] | USA | Migrants | QFT, TSPOT, TST, CXR |
| Hayama et al. [30] | UK | Contacts | TST alone, IGRA (QFT-GIT or T-SPOT) alone, TST +ve followed by IGRA, TST −ve followed by IGRA |
| Jo et al. [11] | USA | Migrants | TST, IGRA |
| Kowada [18] | Japan | Migrants |
TST QFT T-SPOT TST/QFT TST/T-SPOT CXR |
| Kowada [19] | Japan | Migrants, HIV+, contacts |
TST QFT T-SPOT TST/QFT TST/T-SPOT CXR |
| Kowada [21] | Japan | Healthcare workers |
For LTBI: TST, QFT For active TB: CXR |
| Kowada [28] | Japan | HIV+ | QFT, TST, TST/QFT, CXR |
| Kowada [29] | Japan | Other (care home residents) |
TST QFT T-SPOT CXR |
| Kowada [31] | Japan | Contacts | IGRA (QFT-GIT or T-SPOT), TST |
| Kowada [32] | Japan | Immunocompromised |
QFR TSPOT TST CXR |
| Kowada [36] | Japan (assumed) | Healthcare workers | Annual QFT alone vs an initial QFT followed by annual CXR |
| Kowada [38] | Japan (assumed) | Other (Mental health patients who are smokers) |
QFT T-SPOT TST TST followed by QFT TST followed by T-SPOT CXR No screening |
| Kowada [40] | Japan | Children |
QFT TST CXR |
| Laskin et al. [33] | USA | Immunocompromised |
TST IGRA Questionnaire |
| Li et al. [39] | Hong Kong | Other (Older people on entry to residential care) | QFT followed by confirmatory CXR and then smear test |
| Linas et al. [8, 9] | USA | Migrants, contacts, immunocompromised |
1. QFT with 4R 2. QFT with 6H 3. QFT with 3HP 4. TST with 4R 5. TST with 6H 6. TST with 3HP 7. CXR |
| Png et al. [37] | Tertiary care hospital in Singapore | Healthcare workers | QFT |
| Tasillo et al. [10] | USA | Migrants, HIV+ | IGRA |
| Van der Have et al. [34] | Europe | Immuoncompromised |
TST with CXR TST with CXR followed by QFT |