Table 2.
Univariate analyses for the prediction of mortality and the composite outcome, using the clinical and echocardiographic parameters.
| Parameter | HR mortality (CI 95%) | P-value | HR composite outcome (CI 95%) | P-value |
|---|---|---|---|---|
| Age (years) | 1.07 (1.05–1.09) | <0.0001 | 1.05 (1.03–1.07) | <0.0001 |
| Gender (male) | 1.23 (0.66–2.3) | 0.50 | 1.16 (0.68–1.99) | 0.57 |
| Obesity | 1.52 (0.46–9.3) | 0.54 | 1.53 (0.56–6.2) | 0.44 |
| IHD | 1.79 (0.80–3.6) | 0.14 | 1.49 (0.73–2.8) | 0.25 |
| COPD | 2.48 (0.74–6.2) | 0.12 | 3.77 (1.55–7.8) | 0.005 |
| CRF | 4.7 (2.1–9.5) | 0.005 | 3.81 (1.80–7.3) | 0.001 |
| DM | 2.3 (1.26–4.4) | 0.008 | 2.21 (1.28–3.78) | 0.004 |
| HTN | 1.9 (1.02–3.6) | 0.04 | 1.83 (1.07–3.1) | 0.02 |
| Liver disease | 1.86 (0.30–6.1) | 0.43 | 1.26 (0.25–4.0) | 0.75 |
| Immunosuppression | 1.22 (0.20–3.9) | 0.78 | 1.21 (0.37–7.4) | 0.78 |
| ≥1 risk score | 14.7 (3.2–162) | <0.0001 | 4.68 (1.91–15.4) | 0.0002 |
| O2 saturation, % | 1.08 (0.93–1.31) | 0.31 | 1.0 (0.87–1.13) | 0.88 |
| Troponin I, ng/L | 0.98 (0.73–1.03) | 0.74 | 1.06 (1.01–1.09) | 0.01 |
| BNP, pg/mL | 1.008 (1.004–1.02) | 0.0008 | 1.006 (1.002–1.009) | 0.005 |
| Echocardiography | ||||
| EF (%) | 0.98 (0.94–1.05) | 0.69 | 1.00 (0.95–1.05) | 0.95 |
| LVEDD index, mm/m2 | 1.05 (0.95–1.15) | 0.25 | 1.04 (0.96–1.12) | 0.31 |
| LVESD index, mm/m2 | 1.04 (0.93–1.15) | 0.47 | 1.05 (0.96–1.15) | 0.28 |
| LV mass index, gram/m2 | 1.01 (1.00–1.03) | 0.02 | 1.01 (1.00–1.03) | 0.01 |
| LA volume index, ml/m2 | 1.03 (1.01–1.06) | 0.007 | 1.03 (1.01–1.05) | 0.002 |
| RVEDA index, cm2/m2 | 1.1 (0.93–1.29) | 0.24 | 1.01 (0.89–1.16) | 0.78 |
| RVESA, cm2/m2 | 0.98 (0.73–1.28) | 0.90 | 0.84 (0.64–1.08) | 0.18 |
| TAPSE, cm | 0.22 (0.11–0.45) | <0.0001 | 0.26 (0.15–0.47) | <0.0001 |
| RV S′, cm/s | 0.84 (0.73–0.96) | 0.01 | 0.90 (0.80–1.01) | 0.09 |
| RVFAC, % | 1.02 (0.98–1.06) | 0.32 | 1.02 (0.98–1.06) | 0.23 |
| Stroke volume index, cc/m2 | 0.98 (0.94–1.02) | 0.41 | 0.98 (0.95–1.02) | 0.45 |
| Cardiac index, L/m2 | 0.97 (0.66–1.08) | 0.74 | 0.98 (0.77–1.07) | 0.85 |
| E wave velocity, cm/s | 1.01 (1.00–1.03) | 0.01 | 1.01 (1.00–1.03) | 0.02 |
| A wave velocity, cm/s | 1.02 (1.00–1.04) | 0.01 | 1.02 (1.01–1.04) | 0.0001 |
| E/A ratio | 1.00 (0.42–2.1) | 0.98 | 0.61 (0.26–1.27) | 0.19 |
| e′ septal, cm/s | 0.76 (0.64–0.90) | 0.001 | 0.81 (0.69–0.93) | 0.003 |
| e′ lateral, cm/s | 0.79 (0.69–0.89) | <0.0001 | 0.82 (0.74–0.9) | <0.0001 |
| E/e′ average ratio | 1.08 (1.04–1.12) | 0.0005 | 1.07 (1.03–1.10) | 0.001 |
| RA pressure, mmHg | 1.12 (1.04–1.2) | 0.007 | 1.10 (1.03–1.18) | 0.009 |
| SPAP, mmHg͌ | 1.06 (1.02–1.11) | 0.006 | 1.03 (0.99–1.07) | 0.07 |
| PAT, msec | 0.97 (0.96–0.98) | <0.0001 | 0.97 (0.96–0.98) | <0.0001 |
Abbreviations - HR, hazard ratio; CI, confidence interval; IHD, ischemic heart disease; COPD, chronic obstructive pulmonary disease; CRF, chronic renal failure; DM, diabetes mellitus; HTN, hypertension; BNP, brain natriuretic peptide; LV, left ventricular; EF, ejection fraction; LVEDD, left ventricular end diastolic diameter; LVESD, left ventricular end systolic diameter; LA, left atrial; RV, right ventricle; RVEDA, right ventricular end diastolic area; RVESA, right ventricular end systolic area; TAPSE, tricuspid annular plane systolic excursion; RVFAC, right ventricular fractional area change; RA, right atrial; SPAP, systolic pulmonary peak pressure; PAT, pulmonary acceleration time.