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. 2022 Oct 1;55(Pt 5):1368–1376. doi: 10.1107/S1600576722008032

Table 2. The topics of the laboratory exercises.

No. Topic
Compulsory for everybody
Crystallization by slow evaporation of aqueous solutions
1 Crystallization of potassium and chrome alums by slow evaporation using a seed.
2 Crystallization of sodium chloride from pure aqueous solution and from a solution with urea as impurity. The effect on crystal shape.
3 Crystallization of the polymorphs of glycine. The role of impurities.
4 Crystallization of single crystals of cocrystals. L-Ascorbic acid (vitamin C) with L-serine as a case study.
5 Effect of the crystallization conditions on nucleation and nucleus growth.
 
Crystallization from gas phase
6 Crystallization from the gas phase. Benzoic acid as a case study.
 
Crystallization of poorly soluble compounds
7 Crystallization of poorly soluble compounds by counter-diffusion. A case study of calcium carbonate.
8 Crystallization of proteins. Hanging-drop crystallization of lysozyme. Crystallization of lysozyme in a capillary.
 
Optional choices
9 Crystallization in silica glue. Colored gardens.
10 Viedma ripening (KClO3 and γ-glycine as examples).
11 Freeze-drying as a tool of crystallizing highly dispersed but still crystalline particles.
12 Effect of impurities and defects on mechanical properties. Case study of NH4Cl (doping with Cu2+) and NaCl (whiskers).
13 High-pressure crystallization. Water and benzene as case studies. Recrystallization of β-chlorpropamide into γ-chlorpropamide.
14 Crystallization in gels.
15 Artificial minerals grown at high pressures and temperatures.
16 Lisegang rings and crystallization.
17 Redox crystallization. Copper crystals as a case study.
18 Crystal growth from the melt.
19 Crystallization of proteins using robots.
20 Polymorphism control of pharmaceuticals.
21 Sublimation growth of organic crystals.
22 Obtaining crystalline compounds by mechanochemical techniques. Comparison with crystallization from solution/melt.
23 Crystallization by counter-diffusion versus fast mixing of components. Ni di­methyl­glyoximate, multicomponent crystals in ‘glycine–oxalic acid–water–alcohol’ systems, lead oxalate, calcium carbonate and others as case studies.