Table 1.

Smallpox vaccines, cardiac adverse effects, precautions/treatment.

Vaccine	First generation (e.g., Dryvax)	Second generation vaccines (e.g., ACAM2000).	MVA-BN vaccine
Adverse effect	Myocarditis, pericarditis	Myocarditis, pericarditis	Myopericarditis not reported in a Phase II study [19]
Precautions/treatment	NSAIDs, limiting physical exertion for four to six weeks, treatment of heart failure as necessary and steroid therapy	NSAIDs, limiting physical exertion for four to six weeks, treatment of heart failure as necessary and steroid therapy	Counseling on adverse event reporting for proper monitoring