Table 4.
Therapeutic indices (TI) of active compounds, expressed as the ratio of IC50 to TC50
| Drug | VAR-BSH |
VAR-YAM |
VAR-GAR |
MPX |
CPX |
VAC |
||||||
| Vero | LLC-MK2 | Vero | LLC-MK2 | Vero | LLC-MK2 | Vero | LLC-MK2 | Vero | LLC-MK2 | Vero | LLC-MK2 | |
| bis-POM-PMEA | 1.2 | 1.0 | 1.0 | 1.0 | 1.1 | 1.2 | 1.0 | 1.0 | 1.3 | 1.2 | 2.3 | 1.5 |
| HPMPA | 7.9 | 16.4 | 8.8 | 14.7 | 15.2 | 21.7 | 9.2 | 10.9 | 11.9 | 13.0 | 12.3 | 12.5 |
| Cidofovir | 10.5 | 31.3 | 8.3 | 37.0 | 22.2 | 40.0 | 14.9 | 27.0 | 13.3 | 83.3 | 12.3 | 23.3 |
| cHPMPC | 3.2 | 4.9 | 2.8 | 16.4 | 10.1 | 16.9 | 6.5 | 29.4 | 3.0 | 1.0 | 4.4 | 22.7 |
| Ribavirin | 5.4 | 47.6 | 6.3 | 29.4 | 5.9 | 27.8 | 16.9 | 24.4 | 3.3 | 9.4 | 1.0 | 4.2 |
| Tiazofurin | 4.0 | 18.2 | 4.2 | 25.6 | 4.5 | 16.4 | 4.5 | 19.2 | 2.6 | 9.1 | 1.0 | 3.0 |
| C-ca3-Ado | 83.3 | 62.5 | 18.9 | 71.4 | 62.5 | 22.7 | 250 | 125 | 1.0 | 4.0 | 83.3 | 29.4 |
| C3-Npc A | 3333 | 213 | 2500 | 417 | 2500 | 222 | 10000 | 2000 | 1.0 | 1.0 | 5000 | 2000 |
| DFBA | 469 | 1.0 | 536 | 1.0 | 536 | 1.0 | 1250 | 1.0 | 78.9 | 1.0 | 63.6 | 1.0 |
| Methisazone | 3.0 | 2.4 | 2.6 | 2.3 | 4.6 | 2.3 | 1.5 | 1.2 | 2.0 | 2.2 | 2.2 | 1.9 |
Note: For those drugs which have a cytotoxicity >100 μg/ml, the minimum TI is shown and may be larger.